T Cell Precursors to Restore Immune Power After Stem Cell Transplants

Who could benefit from this research

What this research studies

For people who have received an allogeneic hematopoietic stem cell transplant, this project tests a clinically doable method to shorten the period of immune deficiency. The strategy uses donor cells to create T cell precursors in a GMP-compliant system, with the aim that these precursors mature into functional T cells and help prevent infections and relapse. Early results in models suggest these precursors can promote thymus new-formation and support broader immune reconstitution, including natural killer cells and other myeloid cells, without causing graft-versus-host disease. The work envisions a transplant pathway where patients receive enhanced immune rebuilding, potentially reducing infection-related complications and improving long-term disease control.

Why it matters

Where this research is happening

• Sloan-Kettering Inst Can Research
  New York, United States Active

Researchers

• Principal investigator: Tsai, Jennifer Jia-Ying — Sloan-Kettering Inst Can Research
• Study coordinator: Tsai, Jennifer Jia-Ying

Related research

Other NIH-funded projects on the same topics.

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• Inpatient yoga therapy for cancer patients undergoing stem cell transplant

  A randomized trial will test whether an inpatient yoga program helps people receiving stem cell transplants feel better and cope with treatment.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11447334

• A structured peer support program for people having stem cell transplants

  A brief, supportive, phone-based peer program for adults with blood cancers undergoing stem cell transplant to help manage stress and improve recovery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11447086

• Engineering patient avatars to study GVHD after bone marrow transplant

  Researchers are creating patient-specific lab models of the gut, liver, and blood to better understand and prevent GVHD after bone marrow transplant, with a focus on children.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11428942

• Optimizing stem cell transplants to treat non-malignant blood diseases

  A researcher is pursuing a five-year plan to improve stem cell transplantation strategies for non-cancer blood illnesses, with a focus on safer conditioning, better stem cell collection, and gene editing.

  NIH research Washington University · Saint Louis, United States · NIH-11392266

• Positive psychology support for stem cell transplant survivors

  A phone-delivered program helps people who survived stem cell transplantation feel less anxious or depressed and enjoy a higher quality of life.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11383135

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.