Personalized radiation dose planning for nuclear medicine with MIRDsoft
Official title: MIRDsoft radiation dosimetry
Funded at Sloan-Kettering Inst Can Research · NIH-11450435 · Data updated 2026-11-12
This grant improves an open-source dosimetry tool to help doctors tailor radiation doses to individual patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $676,849 |
| NIH project number | 1R01CA304551-01A1 |
| Project ID | NIH-11450435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing nuclear medicine or radiology procedures where dose planning is important could benefit.
✕Less likely to help
Some patients may not directly benefit if their treatment does not require individualized dosimetry.
What this research studies
Researchers will enhance MIRDsoft.org by upgrading internal and CT dosimetry software to handle many different body shapes. They will build a library of over 750 human phantom models to support personalized dose calculations. The work combines bioengineering and software development to make dose estimates more accurate for diverse patients. The project aims to keep pace with advances in personalized medicine in nuclear medicine and radiology.
Why it matters
Potential benefit: If successful, patients could receive more precise, safer radiation doses tailored to their body type.
How similar studies have gone: Open-source dosimetry tools have shown promise, and expanding phantom libraries is a logical next step with expected improvements.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Kesner, Adam Leon — Sloan-Kettering Inst Can Research
- Study coordinator: Kesner, Adam Leon
Related research
Other NIH-funded projects on the same topics.
-
Understand how skeletal muscle nuclei specialize and arrange themselves for proper muscle function
A study to uncover how the hundreds of nuclei in skeletal muscle fibers acquire different roles and positions to keep muscles strong and healthy.
-
Genomic profiling and outcomes of cancers in World Trade Center-exposed survivors and responders
This project looks at the genetic makeup and real-world cancer outcomes in people exposed to the World Trade Center disaster to understand how their cancers behave and respond to treatments.
-
Meaning-Centered Psychotherapy for Mexican Patients with Advanced Cancer
A cancer center in Mexico will test a culturally adapted therapy to help Mexican patients with advanced cancer find meaning, peace, and purpose at the end of life.
-
High-specificity genome-scale cell-surface proteomics to find tumor targets
A cancer research project is trying to map all the proteins on the surface of ultra-rare sarcoma cells to find safe, targeted ways to treat them.
-
Priorities for testing and choosing combination therapies in rhabdoid tumors to guide clinical trials
A coordinated, multi-site effort will rigorously test promising drug combinations in rhabdoid tumors to identify the most promising options for future patient trials.
-
ecDNA in Cancer: Understanding and targeting circular DNA that drives tumor growth
A cancer-focused project to understand how extrachromosomal DNA helps tumors grow and resist treatment, and to develop new ways to target these mechanisms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.