Expanding OncoKB: a scalable knowledgebase to guide precision cancer care
Official title: Expanding OncoKB, a scalable and reliable precision oncology knowledgebase.
Funded at Sloan-Kettering Inst Can Research · NIH-11423008 · Data updated 2026-11-12
A NIH grant to grow OncoKB, a trusted database that helps doctors choose the right cancer treatments based on a patient’s tumor data.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $736,625 |
| NIH project number | 1U24CA315540-01 |
| Project ID | NIH-11423008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer whose tumors have identifiable genetic biomarkers that guide targeted therapy or trial enrollment.
✕Less likely to help
Patients without biomarker testing or without a cancer subtype connected to OncoKB interpretations may see less direct impact.
What this research studies
This project aims to expand OncoKB, a widely used knowledgebase that links genetic changes in tumors to targeted therapies and clinical guidelines. By scaling its data, standardizing interpretations, and ensuring alignment with FDA labels and current research, it will support clinicians at the point of care and researchers studying large cancer cohorts. The work includes integrating the knowledgebase into clinical reports and providing accessible APIs for hospital systems and industry partners. Patients could benefit indirectly through more accurate treatment choices and faster access to trial options as the resource grows.
Why it matters
Potential benefit: If successful, patients may receive more precisely matched therapies and clearer decisions about clinical trial options.
How similar studies have gone: OncoKB is already an established, FDA-recognized resource with broad clinical and research use; expansion builds on proven utility.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Chakravarty, Debyani — Sloan-Kettering Inst Can Research
- Study coordinator: Chakravarty, Debyani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.