Origins and functions of pancreatic cancer–associated fibroblasts in pancreatic cancer
Official title: Origins and functions of pancreatic cancer-associated fibroblasts
Funded at Sloan-Kettering Inst Can Research · NIH-11445074 · Data updated 2026-11-12
A research project studies how certain support cells in pancreatic cancer develop and influence tumor growth, with the aim of finding new treatment approaches.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2021 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $444,325 |
| NIH project number | 2R01CA250917-07 |
| Project ID | NIH-11445074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation in this grant as described; focus is on animal models and tissue analyses.
✕Less likely to help
No direct patient enrollment is described in this grant.
What this research studies
Pancreatic cancer is known for a thick tissue support network that helps the tumor grow. This project plans to use mouse models to trace where cancer-associated fibroblasts come from and how they change once cancer develops. By examining specific fibroblast lineages, researchers hope to understand how these cells both promote and restrain tumor progression. The findings could point to new ways to target the tumor environment and improve therapies for pancreatic cancer patients.
Why it matters
Potential benefit: If successful, the work could lead to therapies that modify the tumor-supporting tissue to slow or stop cancer growth.
How similar studies have gone: Previous studies have shown heterogeneity among cancer-associated fibroblasts, suggesting targeted strategies may be effective.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Sherman, Mara H. — Sloan-Kettering Inst Can Research
- Study coordinator: Sherman, Mara H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.