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Clinical trials and research at New York Blood Center

• 1Clinical trials
• 38NIH research projects
• 1Country

All recruiting trials (1)

• Evaluating the safety of unlicensed cord blood units for transplantation

  This study is testing whether using unlicensed cord blood units for transplantation is safe for patients by looking at any side effects that might happen during or after the treatment.

  Recruiting at 60 sites Phase 2 New York Blood Center · Birmingham, Alabama and 70 other locations · NCT01656603

NIH-funded research (38)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How estrogen hormone therapy may change vaccine responses in adult transgender women

  This study will look at how estrogen hormone therapy in adult transgender women affects their immune response to the seasonal COVID-19 vaccine.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11402531

• Transfusion-driven hyperhemolysis in sickle cell disease

  Aimed at understanding why some sickle cell patients have severe, dangerous reactions to blood transfusions and finding ways to prevent it.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11396278

• How moving or traveling affects HIV prevention and care

  This project looks at whether frequent moving or travel changes access to PrEP (HIV prevention) and HIV care for men who have sex with men in the U.S.

  NIH research New York Blood Center · New York, United States · NIH-11393558

• How bone marrow macrophages affect red blood cell production in polycythemia vera

  This project looks at whether certain bone marrow immune cells and their signals cause too many red blood cells and if blocking those signals could help people with polycythemia vera.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11378743

• Radiation protection that works differently for men and women

  A study to understand why men and women react differently to radiation and to develop a new countermeasure that helps protect blood cells after radiation exposure.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11373057

• Sickle cell bone marrow signals that drive platelet activation and red blood cell production

  A patient-facing look at how sickle cell disease changes bone marrow to boost platelet activity and alter red blood cell formation, which may affect anemia and clotting.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365843

• Erythroblastic island macrophages and their role in sickle cell-related red blood cell production

  This grant looks at how a special type of immune cell in the bone marrow may fix or worsen how red blood cells are made in people with sickle cell disease.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365836

• Altered red blood cell membranes in sickle cell disease and infection

  This grant explores how changes in the red blood cell membrane lipids in people with sickle cell disease and during Babesia infection affect hemolysis, with the aim of finding new ways to reduce anemia.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365828

• Alloimmunization and Humoral Immune Response in Sickle Cell Disease

  This grant studies how red blood cell transfusion can trigger antibodies in people with sickle cell disease and what might reduce that risk.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365818

• Core 1: Human Subjects Core with centralized data and sample handling

  A central unit at the New York Blood Center helps collect and manage high-quality patient samples and clinical data to support four research projects and shares clinical insights with lab scientists.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365812

• Complications of RBC Transfusions in Sickle Cell Disease

  This project explores how blood transfusions affect people with sickle cell disease, aiming to understand when transfusions help or hurt and how immune responses shape outcomes.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11365788

• Sex differences in the bone marrow environment and how they affect stem cell transplants

  This grant looks at why men and women’s bone marrow environments differ and how those differences influence stem cell transplants for blood diseases.

  NIH research New York Blood Center · Rye, UNITED STATES · NIH-11297678

• Growing Babesia microti in human red blood cells

  This project aims to create a lab method to keep Babesia microti growing in human red blood cells so researchers can learn how the parasite gets into and multiplies inside those cells.

  NIH research New York Blood Center · New York, United States · NIH-11247976

• Immune drivers of sickle cell transfusion complications

  This project looks at how immune cells and heme from damaged blood cause inflammation, antibody formation, and dangerous transfusion reactions in people with sickle cell disease.

  NIH research New York Blood Center · New York, United States · NIH-11232370

• When transfusions trigger severe red blood cell breakdown in sickle cell disease

  This research aims to find how immune signals cause dangerous red blood cell destruction after transfusions in adults with sickle cell disease.

  NIH research New York Blood Center · New York, United States · NIH-11117009

• Improving vaccine responses in older adults using a new adjuvant combination

  This study is looking at a new way to make vaccines work better for older adults by using a special ingredient that helps boost their immune response, so they can be better protected against infections.

  NIH research New York Blood Center · New York, United States · NIH-11088844

• How low calcium levels affect blood stem cell function

  This study is looking at how blood-making stem cells work when there's less calcium around, with the hope that understanding this could help improve treatments for blood disorders.

  NIH research New York Blood Center · New York, United States · NIH-11088193

• How Babesia parasites change red blood cells

  This study is looking at how Babesia parasites, which are spread by ticks and can make people and animals sick, change red blood cells, and it aims to find out which specific proteins from the parasites are involved in these changes to help us understand the disease better and find new ways to treat it.

  NIH research New York Blood Center · New York, United States · NIH-11054221

• Exploring how transgender women respond to seasonal COVID-19 vaccines

  This study is looking at how seasonal COVID-19 vaccines affect the immune system and behavior of transgender women who are on hormone therapy, to better understand their unique needs and improve vaccination experiences for them.

  NIH research New York Blood Center · New York, United States · NIH-11053893

• Creating a system to grow Babesia microti in human red blood cells

  This study is working on a new way to grow the Babesia microti parasite in human red blood cells to learn more about how it affects them, which could help improve treatments for babesiosis in the future.

  NIH research New York Blood Center · New York, United States · NIH-11022235

• Understanding how sickle cell disease affects bone marrow and blood cell production

  This project explores how sickle cell disease changes the bone marrow, which might help us understand why patients have issues with blood clotting and red blood cell production.

  NIH research New York Blood Center · New York, United States · NIH-11015294

• Understanding how immune cells affect red blood cell production in sickle cell disease

  This research explores how special immune cells called macrophages in the bone marrow might be causing problems with red blood cell production in people with sickle cell disease.

  NIH research New York Blood Center · New York, United States · NIH-11015293

• Understanding Red Blood Cell Changes in Sickle Cell Disease and Infection

  This research explores why some people with sickle cell disease experience more severe symptoms, especially when they also have an infection, by looking closely at their red blood cells.

  NIH research New York Blood Center · New York, United States · NIH-11015292

• Understanding Immune Reactions to Blood Transfusions in Sickle Cell Disease

  This project aims to understand why some people with sickle cell disease develop immune reactions to blood transfusions, which can make future transfusions difficult and risky.

  NIH research New York Blood Center · New York, United States · NIH-11015291

• Managing Patient Samples and Health Information

  This core helps gather and organize important patient samples and health information for other research projects.

  NIH research New York Blood Center · New York, United States · NIH-11015290

• Understanding Transfusion Effects in Sickle Cell Disease

  This program explores how red blood cell transfusions help or harm patients with sickle cell disease, focusing on immune responses and bone marrow health.

  NIH research New York Blood Center · New York, United States · NIH-11015288

• Understanding the immune response in sickle cell disease

  This study is looking at how sickle cell disease affects the immune system during blood transfusions, aiming to find ways to make transfusions safer and improve health for patients who need them.

  NIH research New York Blood Center · New York, United States · NIH-10995269

• Improving the effectiveness of stem cell therapy for sickle cell disease

  This study is looking at new ways to improve the collection and use of stem cells for gene therapy in people with sickle cell disease, making it easier for patients to get the treatment they need, especially in areas with fewer resources.

  NIH research New York Blood Center · New York, United States · NIH-10954206

• Understanding severe reactions to blood transfusions in sickle cell disease

  This study is looking at how blood transfusions can sometimes cause serious problems for people with sickle cell disease, especially a reaction where both the new and old blood cells can be harmed, and it aims to find out why this happens so we can better prevent and treat these issues.

  NIH research New York Blood Center · New York, United States · NIH-10904817

• Investigating how macrophages respond to hemolytic diseases like sickle cell disease and β-thalassemia

  This study is looking at how certain immune cells called macrophages react to the breakdown of red blood cells in sickle cell disease and β-thalassemia, to help find better treatments for people living with these conditions.

  NIH research New York Blood Center · New York, United States · NIH-10880429

• Understanding how blood cell destruction affects bone marrow health

  This study looks at how the breakdown of red blood cells affects the bone marrow, which is important for making new blood cells, and it aims to find new treatments that could help improve blood health for people with sickle cell disease.

  NIH research New York Blood Center · New York, United States · NIH-10880428

• Investigating blood complications caused by Babesia infections

  This study is looking at how Babesia infections can make things worse for people with sickle cell disease by causing more blood problems, and it hopes to find new ways to help treat these issues.

  NIH research New York Blood Center · New York, United States · NIH-10880426

• Investigating how blood transfusions affect immune responses in sickle cell disease and thalassemia

  This study is looking at how blood transfusions affect the immune system of people with sickle cell disease and thalassemia, to understand why some patients have bad reactions while others don’t, with the hope of making transfusions safer and easier for everyone.

  NIH research New York Blood Center · New York, United States · NIH-10880424

• Optimizing the collection of blood samples and clinical data for research

  This study is all about improving how we collect and manage blood samples and health information to help researchers better understand blood-related conditions and improve care for patients like you.

  NIH research New York Blood Center · New York, United States · NIH-10880423

• Coordination and management of a collaborative research program

  This study is all about helping researchers work better together and stay organized, which could lead to better treatments and outcomes for patients like you in the future.

  NIH research New York Blood Center · New York, United States · NIH-10880421

• Understanding the effects of blood transfusions in patients with blood disorders

  This study is looking at how blood transfusions can help or hurt people with hemoglobin disorders, like sickle cell disease, by checking how these transfusions affect the immune system and overall health, so we can make them safer and more effective for patients.

  NIH research New York Blood Center · New York, United States · NIH-10880420

• Investigating how latexin affects blood cell production and recovery

  This study is looking at a protein called latexin to see how it helps blood stem cells survive tough situations like aging or radiation, with the goal of finding new treatments that could help patients who have trouble making blood cells.

  NIH research New York Blood Center · New York, United States · NIH-10879150

• Understanding how COVID-19 affects blood stem cells over time

  This study is looking at how COVID-19 affects blood stem cells and the immune system over time, and it’s for people who want to help us understand how the virus changes the way our bodies produce blood cells.

  NIH research New York Blood Center · New York, United States · NIH-10836902

Quick answers

How many clinical trials run by New York Blood Center are recruiting right now?

1, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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