Understanding how immune cells affect red blood cell production in sickle cell disease
Erythroblastic Island Macrophages in SCD Disordered Erythropoiesis.
['FUNDING_P01'] · NEW YORK BLOOD CENTER · NIH-11015293
This research explores how special immune cells called macrophages in the bone marrow might be causing problems with red blood cell production in people with sickle cell disease.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK BLOOD CENTER (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11015293 on ClinicalTrials.gov |
What this research studies
Our bodies rely on special cells in the bone marrow, called erythroblastic island macrophages, to help make healthy red blood cells. In sickle cell disease, these macrophages may not work correctly, leading to issues with red blood cell formation and anemia. This project aims to understand how these macrophages become dysfunctional and how their communication with developing red blood cells is disrupted. We are looking at specific signals and pathways within these cells to find ways to restore their normal function and improve red blood cell production.
Who could benefit from this research
Good fit: This foundational research is for patients with sickle cell disease who may benefit from future therapies that improve red blood cell production.
Not a fit: Patients without sickle cell disease or related blood disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help the body produce more healthy red blood cells, potentially reducing anemia and other complications for individuals with sickle cell disease.
How similar studies have performed: While the role of these macrophages in red blood cell production is known, this specific approach to understanding their dysfunction in sickle cell disease is exploring new mechanisms.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK BLOOD CENTER — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AN, XIULI — NEW YORK BLOOD CENTER
- Study coordinator: AN, XIULI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Babesia infection, Babesia parasite infection, Blood Diseases