Investigating how macrophages respond to hemolytic diseases like sickle cell disease and β-thalassemia
Macrophage Functional Response in Hemolytic Complications
['FUNDING_P01'] · NEW YORK BLOOD CENTER · NIH-10880429
This study is looking at how certain immune cells called macrophages react to the breakdown of red blood cells in sickle cell disease and β-thalassemia, to help find better treatments for people living with these conditions.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK BLOOD CENTER (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10880429 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of macrophages in hemolytic diseases, particularly sickle cell disease (SCD) and β-thalassemia (THAL). It aims to explore how different types of hemolysis affect inflammation levels in these conditions. By using mouse models, the researchers will compare the inflammatory responses of macrophages in SCD and THAL, examining how fresh and old red blood cell transfusions influence these responses. The goal is to uncover mechanisms that could lead to better treatment strategies for patients suffering from these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with sickle cell disease or β-thalassemia.
Not a fit: Patients with other types of hemolytic disorders not specifically related to SCD or THAL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with hemolytic diseases, potentially reducing inflammation and associated complications.
How similar studies have performed: Previous research has shown promising results in understanding macrophage responses in hemolytic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK BLOOD CENTER — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VINCHI, FRANCESCA — NEW YORK BLOOD CENTER
- Study coordinator: VINCHI, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Babesia infection, Babesia parasite infection