Investigating how macrophages respond to hemolytic diseases like sickle cell disease and β-thalassemia
Official title: Macrophage Functional Response in Hemolytic Complications
Funded at New York Blood Center · NIH-10880429 · Data updated 2026-11-12
This study is looking at how certain immune cells called macrophages react to the breakdown of red blood cells in sickle cell disease and β-thalassemia, to help find better treatments for people living with these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 20, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $480,712 |
| NIH project number | 5P01HL149626-05 |
| Project ID | NIH-10880429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with sickle cell disease or β-thalassemia.
✕Less likely to help
Patients with other types of hemolytic disorders not specifically related to SCD or THAL may not benefit from this research.
What this research studies
This research focuses on understanding the role of macrophages in hemolytic diseases, particularly sickle cell disease (SCD) and β-thalassemia (THAL). It aims to explore how different types of hemolysis affect inflammation levels in these conditions. By using mouse models, the researchers will compare the inflammatory responses of macrophages in SCD and THAL, examining how fresh and old red blood cell transfusions influence these responses. The goal is to uncover mechanisms that could lead to better treatment strategies for patients suffering from these diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with hemolytic diseases, potentially reducing inflammation and associated complications.
How similar studies have gone: Previous research has shown promising results in understanding macrophage responses in hemolytic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Vinchi, Francesca — New York Blood Center
- Study coordinator: Vinchi, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.