Understanding the effects of blood transfusions in patients with blood disorders
Official title: Complications of Hemolysis and Transfusion Therapy
Funded at New York Blood Center · NIH-10880420 · Data updated 2026-11-12
This study is looking at how blood transfusions can help or hurt people with hemoglobin disorders, like sickle cell disease, by checking how these transfusions affect the immune system and overall health, so we can make them safer and more effective for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 20, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $3,041,589 |
| NIH project number | 5P01HL149626-05 |
| Project ID | NIH-10880420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with hemoglobinopathies, such as sickle cell disease or thalassemia, who may require blood transfusions.
✕Less likely to help
Patients without hemoglobin disorders or those who do not require blood transfusions are unlikely to benefit from this research.
What this research studies
This research investigates how red blood cell transfusions affect patients with hemoglobin disorders, particularly focusing on the balance between beneficial and harmful effects. It explores the role of free hemoglobin and heme in causing complications such as inflammation and oxidative stress. By examining immune responses and the bone marrow environment during transfusions, the research aims to improve transfusion outcomes and reduce complications associated with conditions like sickle cell disease. Patients may be involved in studies assessing their immune response and transfusion effects.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective blood transfusion protocols for patients with hemoglobin disorders.
How similar studies have gone: Previous research has shown promising results in understanding the immune response to transfusions, indicating that this approach may lead to significant advancements.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Yazdanbakhsh, Karina — New York Blood Center
- Study coordinator: Yazdanbakhsh, Karina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.