Understanding how blood cell destruction affects bone marrow health
Official title: Hemolysis and the Hematopoietic Niche
Funded at New York Blood Center · NIH-10880428 · Data updated 2026-11-12
This study looks at how the breakdown of red blood cells affects the bone marrow, which is important for making new blood cells, and it aims to find new treatments that could help improve blood health for people with sickle cell disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 20, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $737,425 |
| NIH project number | 5P01HL149626-05 |
| Project ID | NIH-10880428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease who may benefit from new therapeutic strategies targeting bone marrow health.
✕Less likely to help
Patients without sickle cell disease or those who do not experience hemolysis may not receive any benefit from this research.
What this research studies
This research investigates the impact of hemolysis, or the destruction of red blood cells, on the bone marrow environment, which is crucial for producing new blood cells. The study focuses on how this destruction affects the niches that support hematopoietic stem cells and erythroid progenitors. By exploring the mechanisms behind these changes, the research aims to identify potential therapies, such as transfusions or heme scavengers, that could improve bone marrow function and overall blood health for patients with sickle cell disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with sickle cell disease, enhancing their quality of life and health outcomes.
How similar studies have gone: Other research has shown promising results in understanding the bone marrow microenvironment in relation to blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: An, Xiuli — New York Blood Center
- Study coordinator: An, Xiuli
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.