Investigating how latexin affects blood cell production and recovery
Official title: Latexin function in the maintenance and regeneration of the hematopoietic system
Funded at New York Blood Center · NIH-10879150 · Data updated 2026-11-12
This study is looking at a protein called latexin to see how it helps blood stem cells survive tough situations like aging or radiation, with the goal of finding new treatments that could help patients who have trouble making blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $427,000 |
| NIH project number | 5R01HL124015-09 |
| Project ID | NIH-10879150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have undergone radiation therapy or those experiencing age-related blood cell production issues.
✕Less likely to help
Patients with stable hematopoietic function and no history of radiation exposure or age-related decline may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called latexin in the maintenance and regeneration of the hematopoietic system, which is responsible for producing blood cells. The study aims to identify new pharmaceutical compounds that can enhance the survival of hematopoietic stem cells (HSCs) under stress conditions, such as radiation and aging. By exploring the mechanisms through which latexin influences HSC function, the research seeks to develop potential treatments that could protect against blood system damage and improve recovery after stress. Patients may benefit from insights gained in this research, particularly those affected by conditions that compromise blood cell production.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance blood cell production and recovery in patients undergoing radiation therapy or experiencing age-related decline in blood cell function.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for enhancing hematopoietic stem cell function, suggesting that this approach may yield beneficial results.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Liang, Ying — New York Blood Center
- Study coordinator: Liang, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.