Understanding the immune response in sickle cell disease
Official title: Immune Pathophysiology of Sickle Cell Disease
Funded at New York Blood Center · NIH-10995269 · Data updated 2026-11-12
This study is looking at how sickle cell disease affects the immune system during blood transfusions, aiming to find ways to make transfusions safer and improve health for patients who need them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2022 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $828,377 |
| NIH project number | 5R35HL161239-04 |
| Project ID | NIH-10995269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sickle cell disease who have received or are likely to receive blood transfusions.
✕Less likely to help
Patients without sickle cell disease or those who do not require blood transfusions may not benefit from this research.
What this research studies
This research investigates the chronic inflammation associated with sickle cell disease (SCD) and its impact on patients, particularly focusing on the immune mechanisms that lead to complications from blood transfusions. The study aims to explore how certain immune cells, specifically monocytes, respond to hemolysis and contribute to transfusion-related complications such as alloimmunization and delayed transfusion reactions. By examining these pathways, the research seeks to identify potential therapeutic targets that could improve patient outcomes. Patients with SCD who require blood transfusions may benefit from a better understanding of their immune responses and the development of safer transfusion practices.
Why it matters
Potential benefit: If successful, this research could lead to improved transfusion safety and reduced complications for patients with sickle cell disease.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in transfusion complications, indicating that this approach has potential for success.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Yazdanbakhsh, Karina — New York Blood Center
- Study coordinator: Yazdanbakhsh, Karina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.