Understanding how COVID-19 affects blood stem cells over time
Official title: Mechanism of the short- and long-term effects of COVID-19-induced Alarmins on hematopoietic stem and progenitor cells.
Funded at New York Blood Center · NIH-10836902 · Data updated 2026-11-12
This study is looking at how COVID-19 affects blood stem cells and the immune system over time, and it’s for people who want to help us understand how the virus changes the way our bodies produce blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $435,732 |
| NIH project number | 7R01DK130478-03 |
| Project ID | NIH-10836902 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have recovered from COVID-19 and are experiencing ongoing health issues related to blood cell production.
✕Less likely to help
Patients who have not had COVID-19 or those without any hematological concerns may not benefit from this research.
What this research studies
This research investigates the long-term effects of COVID-19 on blood stem cells and the immune system. It focuses on how the virus alters the function and differentiation of hematopoietic stem cells (HSCs) through the release of specific proteins called alarmins. By examining the pathways involved, the study aims to uncover the mechanisms behind these changes and their implications for blood cell production. Patients may be involved in providing samples or data to help understand these effects better.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from long-term effects of COVID-19 on blood health.
How similar studies have gone: While the specific mechanisms of COVID-19's impact on blood stem cells are still being explored, related research has shown that viral infections can significantly affect hematopoiesis, suggesting potential for impactful findings in this area.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Liang, Ying — New York Blood Center
- Study coordinator: Liang, Ying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.