How low calcium levels affect blood stem cell function
Official title: Hormetic ER Stress Regulation of Hematopoietic Stem Cell Function
Funded at New York Blood Center · NIH-11088193 · Data updated 2026-11-12
This study is looking at how blood-making stem cells work when there's less calcium around, with the hope that understanding this could help improve treatments for blood disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Blood Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 3, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $495,320 |
| NIH project number | 5R01HL155574-05 |
| Project ID | NIH-11088193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or conditions that affect blood cell production.
✕Less likely to help
Patients with stable blood conditions or those not requiring stem cell therapies may not receive direct benefits from this research.
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are responsible for producing blood cells, function under low calcium conditions. The study explores the molecular mechanisms that regulate blood cell production and how altering the calcium environment can enhance the effectiveness of HSCs. By using specific culture media with reduced calcium, researchers aim to improve the survival and function of these stem cells, potentially leading to better treatments for blood disorders. Patients may benefit from insights gained into optimizing HSC function for therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with blood disorders by enhancing the function of hematopoietic stem cells.
How similar studies have gone: Other research has shown promising results in enhancing stem cell function through environmental modifications, suggesting potential for success in this approach.
Where this research is happening
-
New York Blood Center
New York, United States Active
Researchers
- Principal investigator: Luchsinger, Larry L — New York Blood Center
- Study coordinator: Luchsinger, Larry L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.