Sponsor or institution
Clinical trials and research at Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
As of November 12, 2026, Find a Trial lists 32 clinical trials run by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta that are recruiting, at sites in 2 countries (most in Italy (32), Spain (1)). By phase: Phase 2/3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 32Clinical trials
- 2Countries
Newest trials
All recruiting trials (32)
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Natural history and genotype-phenotype patterns in mitochondrial leukoencephalopathies
This study looks at how mitochondrial leukoencephalopathies develop over time and how genetic differences relate to what patients experience.
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A real-world look at trigeminal autonomic cephalalgias in Italy
This study follows adults with TACs like cluster headache and related conditions in routine care to see how treatments work and what factors influence outcomes over time.
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Patient experiences during treatment for IDH‑mutant grade 2 gliomas: vorasidenib, radiotherapy, or observation
This project will test how adults with IDH‑mutant grade 2 gliomas feel—their quality of life, treatment symptoms, and anxiety—when they receive vorasidenib, radiotherapy, or active surveillance.
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Nerve function and structure in CMT, anti‑MAG neuropathy, and CIDP
This project will test nerve‑conduction, axonal‑excitability, skin biopsy, and ultrasound measures in adults with CMT, CIDP, or anti‑MAG neuropathy to see if they better describe nerve function and structure.
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Gut barrier and gut microbes in children with autism
This trial will test whether a one-month course of postbiotic supplements can improve gut symptoms and behavior in children with autism aged 3–8.
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Heart rate variability and processed EEG to predict recovery after cranial neurosurgery
This project will test whether measuring heart rate variability and processed EEG during and after brain surgery can help predict early postoperative problems for adults having elective cranial neurosurgery.
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Italian version of the GIDS-PD (Gastrointestinal Dysfunction Scale for Parkinson's disease)
This project will test an Italian translation of the Gastrointestinal Dysfunction Scale for people with Parkinson's disease to help measure stomach and bowel symptoms.
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Tracking visuospatial difficulties over time in people with parietal lobe glioma
This project will test whether visuospatial problems in adults with parietal lobe glioma get better, worse, or stay the same before and after surgical removal of the tumor.
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Fluorescence-enhanced stereotactic biopsy needle for tumor and vessel detection
This project will test a biopsy needle fitted with 5-ALA fluorescence, Raman spectroscopy, and ultrasound to see if it can identify tumor tissue and blood vessels in adults with high-grade glioma.
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Single-cell profiling of peripheral nerves to find blood and skin biomarkers and new targets for ALS
This project will try to find proteins in peripheral nerves, blood, and skin that signal early ALS in adults with recent-onset disease, people with genetic risk, and healthy controls.
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Ultrasound-guided versus landmark-based botulinum toxin injections for cervical dystonia
This trial will try ultrasound-guided botulinum toxin injections to see if adults with idiopathic cervical dystonia have better quality of life and similar safety compared with injections done using anatomical landmarks.
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IV sodium fluorescein to highlight suspected CNS tumors during surgery
This study tests whether giving a small IV dose of sodium fluorescein during surgery helps surgeons see and remove suspected malignant brain and spinal tumors in people of any age.
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Neuropsychological and cognitive profile in adults with migraine
This project will test how thinking skills and psychological factors (like anxiety, depression, worry, and coping) relate to migraine in adults who have had migraine for at least one year.
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Genetic profiles linked to ruptured and unruptured brain aneurysms
This project will test whether genetic differences in adults with saccular brain aneurysms are linked to rupture risk by comparing people with ruptured and unruptured aneurysms to healthy controls.
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Cholesterol metabolism and biomarker links in neurodegenerative dementias
We will measure cholesterol metabolites in brain tissue, spinal fluid, and blood to see if they relate to disease severity and progression in people with Alzheimer's disease, frontotemporal dementia, and related tauopathies.
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Unilateral focused ultrasound pallidotomy for medication‑resistant limb dystonia
This will test whether a non‑invasive focused ultrasound procedure can reduce arm or leg dystonia symptoms in adults who haven't improved with medicines or botulinum toxin.
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Pain Reprocessing Therapy for chronic orofacial pain
This study will try Pain Reprocessing Therapy, a CBT-based psychotherapy, to reduce pain and improve function in adults with chronic primary orofacial pain who report moderate to severe pain.
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Comparing EEG indicators to assess mindfulness therapy for migraine relief
This study is testing if mindfulness therapy can help people with frequent migraines feel better by looking at brain activity and using wearable devices to track progress at home.
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Analyzing genetic and imaging features in CADASIL patients
This study is trying to see how genetic and brain imaging information can help doctors better understand and treat CADASIL in patients with specific genetic markers.
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Impact of the Mediterranean Diet on patients with CADASIL and Cerebral Amyloid Angiopathy
This study is testing whether following the Mediterranean Diet can help people with CADASIL and Cerebral Amyloid Angiopathy feel better and reduce their risk of strokes and cognitive decline.
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Improving care pathways for patients with rare brain tumors using AI
This study is testing whether using AI to improve treatment plans can help people with rare brain tumors have better care and quality of life through a home rehabilitation program.
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Evaluating the impact of anesthesia on recovery after brain surgery
This study is testing how different amounts of anesthesia during brain surgery affect how quickly patients wake up and recover afterward.
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Observational study on cancer risk in children with PTEN gene mutations
This study is trying to understand the cancer risks in children with PTEN gene mutations to help improve how they are monitored and treated.
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Observational study on patients undergoing endovascular treatment for vascular conditions
This study looks at patients of all ages getting endovascular treatment for brain or spine blood vessel issues to see how they do before and after the procedure and to find out what might affect their recovery.
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Diagnosis and treatment of drug-resistant focal epilepsies
This study is testing if surgery to remove the area of the brain causing seizures can help people with drug-resistant focal epilepsy feel better and have fewer seizures.
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Assessing psychological and psychiatric factors in epilepsy surgery candidates
This study looks at how surgery for drug-resistant epilepsy affects the mental health and quality of life of patients, comparing those who have surgery right away with those who wait.
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Evaluating outcomes in neurosurgery using standardized measures
This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.
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Investigating brain network dynamics in dystonia patients with deep brain stimulation
This study looks at how deep brain stimulation affects brain activity in people with dystonia to see if it helps improve their symptoms.
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Using a digital twin app to support people in secondary prevention after stroke, Moyamoya disease, or cerebral amyloid angiopathy
This trial will try the STRATIF-AI app plus usual secondary prevention care to see if it improves daily self-care and the patient experience for adults after stroke, Moyamoya disease, or CAA.
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Comparing anesthesia models for neurosurgery patients in intensive care
This study is testing how well certain anesthesia models work for patients recovering from brain surgery in the ICU to see if they help manage sedation better than during the surgery itself.
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Long-term observation of ultra-rare inherited neurological diseases.
This study is looking to learn more about very rare inherited neurological diseases by tracking and collecting information from patients over a long time to see how these conditions change and affect their lives.
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Identifying biomarkers for cerebral amyloid angiopathy
This study is trying to find signs that show how cerebral amyloid angiopathy affects older people, to help doctors better understand and treat the condition.
Quick answers
How many clinical trials run by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta are recruiting right now?
32, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in Italy (32 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.