Genetic profiles linked to ruptured and unruptured brain aneurysms
Genetic Profile in Patients With Ruptured and Unruptured Intracranial Aneurysms: Observational Study Aimed at Identifying Genetic Variants Associated With the Risk of Intracranial Aneurysm Rupture
This project will test whether genetic differences in adults with saccular brain aneurysms are linked to rupture risk by comparing people with ruptured and unruptured aneurysms to healthy controls.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 252 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Academic / other |
| Locations | 1 site (Milan, MI) |
| Trial ID | NCT07233915 on ClinicalTrials.gov |
What this trial studies
This multicenter observational project in Italy will enroll 400 patients with saccular intracranial aneurysms (200 ruptured, 200 unruptured) and 200 healthy controls over two years. Anonymized clinical data and peripheral blood samples will be collected from each participant, with aneurysm wall tissue obtained when available during routine care. Genomic analyses will be performed and data stored in a central biorepository, while treatment and follow-up remain unchanged and are determined by treating vascular teams. Participants provide informed consent, are assigned coded identifiers, and no extra clinical procedures beyond standard practice are required.
Who should consider this trial
Good fit: Adults aged 18–80 with a diagnosed saccular intracranial aneurysm (ruptured or unruptured) who can give informed consent are ideal candidates.
Not a fit: People with non-saccular aneurysms or those unable to provide informed consent are not eligible and therefore will not benefit from participation.
Why it matters
Potential benefit: If successful, this could identify genetic markers that help predict which aneurysms are more likely to rupture, improving risk stratification and informing treatment choices.
How similar studies have performed: Previous genetic studies have identified some loci linked to intracranial aneurysm formation, but robust genetic predictors of rupture are still limited, so this approach builds on preliminary evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 80 years, of both sexes * Patients diagnosed with ruptured or unruptured saccular intracranial aneurysms (sIA) Exclusion Criteria: * Patients with non-saccular intracranial aneurysms * Patients unable to provide informed consent due to language impairment or altered consciousness, in the absence of a legally appointed guardian
Where this trial is running
Milan, MI
- Fondazione IRCCS Istituto Neurologico Carlo Besta — Milan, Mi, Italy (Recruiting)
Study contacts
- Study coordinator: Marco P Schiariti, MD
- Email: marco.schiariti@istituto-besta.it
- Phone: + 39 02.2394
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.