Genetic profiles linked to ruptured and unruptured brain aneurysms
Official title: Genetic Profile in Patients With Ruptured and Unruptured Intracranial Aneurysms: Observational Study Aimed at Identifying Genetic Variants Associated With the Risk of Intracranial Aneurysm Rupture
Run by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · NCT07233915 · Data updated 2026-11-12
This project will test whether genetic differences in adults with saccular brain aneurysms are linked to rupture risk by comparing people with ruptured and unruptured aneurysms to healthy controls.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 252 (estimated) |
| Sponsor | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Academic / other |
| Locations | 1 site (Milan, MI) |
| Status | Recruiting |
| Started | February 6, 2014 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT07233915 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with a diagnosed saccular intracranial aneurysm (ruptured or unruptured) who can give informed consent are ideal candidates.
✕Probably not a fit
People with non-saccular aneurysms or those unable to provide informed consent are not eligible and therefore will not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational project in Italy will enroll 400 patients with saccular intracranial aneurysms (200 ruptured, 200 unruptured) and 200 healthy controls over two years. Anonymized clinical data and peripheral blood samples will be collected from each participant, with aneurysm wall tissue obtained when available during routine care. Genomic analyses will be performed and data stored in a central biorepository, while treatment and follow-up remain unchanged and are determined by treating vascular teams. Participants provide informed consent, are assigned coded identifiers, and no extra clinical procedures beyond standard practice are required.
Why it matters
Potential benefit: If successful, this could identify genetic markers that help predict which aneurysms are more likely to rupture, improving risk stratification and informing treatment choices.
How similar studies have gone: Previous genetic studies have identified some loci linked to intracranial aneurysm formation, but robust genetic predictors of rupture are still limited, so this approach builds on preliminary evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 80 years, of both sexes * Patients diagnosed with ruptured or unruptured saccular intracranial aneurysms (sIA) Exclusion Criteria: * Patients with non-saccular intracranial aneurysms * Patients unable to provide informed consent due to language impairment or altered consciousness, in the absence of a legally appointed guardian
Where it's running
-
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Mi, Italy Recruiting
Study contacts
- Study coordinator: Marco P Schiariti, MD
- Email: marco.schiariti@istituto-besta.it
- Phone: + 39 02.2394
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.