Nerve function and structure in CMT, anti‑MAG neuropathy, and CIDP

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will perform conventional nerve‑conduction studies and axonal‑excitability testing using the TRONDF protocol in adults with selected forms of Charcot‑Marie‑Tooth disease and compare findings to patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and anti‑MAG neuropathy. The protocol also includes analysis of nerve fibers from skin biopsy in CMT patients and ultrasound imaging of nerves from the wrist to the axilla and of intrinsic hand muscles. Axonal‑excitability testing uses paired electrical stimuli with varying intensity and a conditioning stimulus of variable duration to probe axonal membrane and ion‑channel behavior. Physiological measures will be correlated with clinical and genetic classifications to explore potential diagnostic and prognostic value.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The subject is ≥ 18 years old.

   AND:
2. A genetically confirmed diagnosis of one of the several CMT subtypes (i.e., CMT1A, CMT1B, CMTX1, CMT2I/J, CMT4B, CMT4D and CMT4J) OR
3. A clinical diagnosis of either Chronic Inflammatory Demyelinating Polyneuropathy or anti-MAG polyneuropathy

Exclusion Criteria:

1. Known neuropathy from another cause (e.g., diabetes, chronic renal insufficiency, medications, alcohol), including previous carpal tunnel syndrome surgery.
2. History of exposure to chemotherapeutic agents (e.g., bortezomib, vincristine, cisplatin, taxol, vedotin/auromycin-conjugated antibodies), or other medications (e.g., disulfuram, thalidomide, voriconizole, chronic colchicine use) that can cause neuropathy, active alcohol abuse.
3. History of cancer, other than skin cancer, within 5 years prior to enrollment.
4. Pregnancy or nursing.
5. Known systemic disease that predisposes to neuropathy.
6. Other central nervous system diseases.

Where it's running

• Fondazione IRCCS Istituto Neurologico Carlo Besta
  Milan, Italy Recruiting

Study contacts

• Principal investigator: Davide Pareyson, MD — Fondazione IRCCS Istituto Neurologico Carlo Besta
• Study coordinator: Davide Pareyson, MD
• Email: davide.pareyson@istituto-besta.it
• Phone: + 39 02.2394

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.