Tracking visuospatial difficulties over time in people with parietal lobe glioma
Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · NCT07286929
This project will test whether visuospatial problems in adults with parietal lobe glioma get better, worse, or stay the same before and after surgical removal of the tumor.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Milan) |
| Trial ID | NCT07286929 on ClinicalTrials.gov |
What this trial studies
This single-center, prospective observational study will enroll 40 adults with low- or high-grade parietal lobe glioma who are candidates for surgical resection. Participants will complete a battery of visuospatial neuropsychological tests (Line Bisection, Bell and Letter Cancellation, Apple Cancellation, Reading test, Fluff test) at pre-surgery screening and at approximately 3–4 months and 6 months after surgery. Test performance will be compared to normative cut-offs and correlated with patient-reported ADL/IADL measures, MRI radiology, and histological/molecular tumor data. The study aims to define the prevalence and temporal pattern of visuospatial deficits to guide personalized treatment and rehabilitation pathways.
Who should consider this trial
Good fit: Adults over 18 who speak Italian, have a suspected parietal lobe glioma, and are planned for surgical resection without prior chemotherapy or radiotherapy and without other major CNS or neurodegenerative disease.
Not a fit: Patients with tumors outside the parietal lobe, those unable to undergo resection, those with prior chemo/radiation, or with other major CNS or neurodegenerative conditions are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, results could help tailor post-surgical rehabilitation and surgical planning to better preserve daily functioning in patients with parietal lobe glioma.
How similar studies have performed: Similar neuropsychological methods have been used to characterize visuospatial deficits after stroke and brain injury with useful results, but longitudinal data specifically in parietal lobe glioma patients are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \>18 years old * Patients must understand the Italian Language * Patients with suspected parietal lobe glioma Exclusion Criteria: * Tumor site other than parietal lobe. * Patients who cannot undergo surgical resection (stereotactic/open biopsy). * Patients who received a previous chemotherapy and/or radiotherapy treatment. * Patients with a history of intracranial mass lesion or traumatic brain injury. * Patients with a history of other CNS diseases (e.g., stroke, metastasis). * Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).
Where this trial is running
Milan
- Fondazione IRCCS Istituto Neurologico Carlo Besta — Milan, Italy (RECRUITING)
Study contacts
- Principal investigator: Francesco Di Meco, MD — Fondazione IRCCS Istituto Neurologico Carlo Besta
- Study coordinator: Francesco Di Meco, MD
- Email: francesco.dimeco@istituto-besta.it
- Phone: + 39 02.2394
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glioma, Parietal Lobe Glioma, Visuspatial Deficit, Unilateral Spatial Neglect, Visuospatial deficit, Parietal Lobe, Neuropsychological assessment, Hemineglect