Evaluating the impact of anesthesia on recovery after brain surgery
Official title: FASt Track in Elective Neurosurgery: the Role of Low Propofol Bis-NOL Guided General Anaesthesia for Full, Early and Safe Awakening
Run by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · NCT06844838 · Data updated 2026-11-12
This study is testing how different amounts of anesthesia during brain surgery affect how quickly patients wake up and recover afterward.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | January 19, 2024 |
| Main results expected | December 31, 2025 |
| Study ends | February 1, 2026 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT06844838 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older undergoing elective surgery for supratentorial brain tumors.
✕Probably not a fit
Patients with psychiatric illnesses, cognitive decline, or those under 18 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess how different dosages of sedation during elective neurosurgery affect patients' awakening and recovery of consciousness. Over a 24-month period, data will be collected from patients undergoing supratentorial brain tumor surgery, focusing on preoperative clinical and socio-demographic information, as well as psychological variables. The study will utilize BIS-guided general anesthesia, monitoring various physiological parameters and assessing recovery through a structured awakening chart and patient interactions. The findings will contribute to understanding optimal anesthesia practices for improved patient outcomes.
Why it matters
Potential benefit: If successful, this study could enhance recovery protocols for patients undergoing brain surgery, leading to safer and quicker awakenings.
How similar studies have gone: While there have been studies on anesthesia and recovery, this specific approach using BIS-guided anesthesia in neurosurgery is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with supra- and sub tentorial neurosurgical pathology who meet the following inclusion criteria will be enrolled: * Age greater than or equal to 18 years Exclusion Criteria: * Psychiatric illness in history and/or taking psychotropic drugs * Glasgow Coma Score (GCS) \< 15 * Presence of overt cognitive decline or speech disorders * Patients younger than 18 years of age * Intraoperative hypothermia (\< 36°) * Intraoperative hypotension (MAP \< 20% of baseline)
Where it's running
-
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy Recruiting
Study contacts
- Study coordinator: Carla Carozzi, M.D.
- Email: carla.carozzi@istituto-besta.it
- Phone: +39 02 2394
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.