Improving care for patients with ARDS, pneumonia, and sepsis
Official title: Coordination for ARDS, Pneumonia, and Sepsis supporting Training, Organization and Network Efficiency (CAPSTONE)
Funded at Vanderbilt University Medical Center · NIH-11087519 · Data updated 2026-11-12
This study is all about improving care for people with serious lung issues like ARDS, pneumonia, and sepsis by gathering and analyzing data from a diverse group of patients, so we can better understand these conditions and find the best treatments for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $6,154,585 |
| NIH project number | 5U01HL168478-03 |
| Project ID | NIH-11087519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with ARDS, pneumonia, or sepsis who are willing to participate in a longitudinal study.
✕Less likely to help
Patients with chronic respiratory conditions or those who do not meet the criteria for ARDS, pneumonia, or sepsis may not benefit from this research.
What this research studies
This research focuses on enhancing the care and outcomes for patients suffering from Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis. It aims to create a robust clinical and translational research infrastructure that will support the enrollment of a diverse patient cohort and the collection of comprehensive data over time. By analyzing this data, researchers hope to uncover the underlying mechanisms of these critical illnesses and identify different patient profiles to tailor treatments more effectively. The project involves collaboration among leading medical institutions to ensure high-quality research practices.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better recovery outcomes for patients with ARDS, pneumonia, and sepsis.
How similar studies have gone: Previous research has shown success in improving patient outcomes through coordinated clinical research efforts in critical care settings.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Self, Wesley H — Vanderbilt University Medical Center
- Study coordinator: Self, Wesley H
Related research
Other NIH-funded projects on the same topics.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
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Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
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Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
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Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
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Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next y
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Understanding the recovery patterns of patients with ARDS, pneumonia, and sepsis
This study is looking for people who have had serious breathing problems, like ARDS, pneumonia, or sepsis, to learn more about their recovery and find ways to better predict and improve their health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.