Understanding the recovery patterns of patients with ARDS, pneumonia, and sepsis
Official title: Phenotyping ARDS, Pneumonia, and Sepsis over time to elucidate shared and distinct trajectories ofillness and recovery
Funded at University of Pennsylvania · NIH-11086824 · Data updated 2026-11-12
This study is looking for people who have had serious breathing problems, like ARDS, pneumonia, or sepsis, to learn more about their recovery and find ways to better predict and improve their health outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $634,751 |
| NIH project number | 5U01HL168419-03 |
| Project ID | NIH-11086824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with ARDS, pneumonia, or sepsis.
✕Less likely to help
Patients with chronic respiratory conditions unrelated to ARDS, pneumonia, or sepsis may not benefit from this research.
What this research studies
This research focuses on enrolling patients who have experienced acute respiratory distress syndrome (ARDS), pneumonia, or sepsis to better understand their illness and recovery trajectories. By analyzing clinical and molecular features, the study aims to identify distinct subtypes of these conditions that can predict outcomes such as organ failure and long-term disability. Patients will be monitored over time, and their blood samples will be analyzed to uncover biomarkers associated with recovery and complications. This approach seeks to improve risk assessment and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans and improved recovery outcomes for patients suffering from ARDS, pneumonia, and sepsis.
How similar studies have gone: Previous research has shown promise in identifying molecular subtypes in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Meyer, Nuala Jennings — University of Pennsylvania
- Study coordinator: Meyer, Nuala Jennings
Related research
Other NIH-funded projects on the same topics.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
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Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
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Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
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Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
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Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next y
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Improving care for patients with ARDS, pneumonia, and sepsis
This study is all about improving care for people with serious lung issues like ARDS, pneumonia, and sepsis by gathering and analyzing data from a diverse group of patients, so we can better understand these conditions and find the best treatments for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.