Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
Official title: Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing
Funded at University of California, San Francisco · NIH-11087677 · Data updated 2026-11-12
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next year.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $539,256 |
| NIH project number | 5U01HL168415-03 |
| Project ID | NIH-11087677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing ARDS, pneumonia, or sepsis.
✕Less likely to help
Patients with chronic respiratory conditions or those not currently experiencing ARDS, pneumonia, or sepsis may not benefit from this research.
What this research studies
This research focuses on understanding the molecular differences in patients suffering from Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis. By enrolling 1,000 participants across four clinical sites in California, the study aims to collect extensive clinical data and biological samples to identify distinct molecular phenotypes. Participants will be followed up at 3, 6, and 12 months to assess their recovery and health outcomes. The research utilizes advanced techniques like metagenomic sequencing to analyze the biological factors contributing to these critical conditions.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with ARDS, pneumonia, and sepsis.
How similar studies have gone: Previous research has shown promise in identifying molecular phenotypes in ARDS and utilizing metagenomic sequencing, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Calfee, Carolyn — University of California, San Francisco
- Study coordinator: Calfee, Carolyn
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
-
Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
-
Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
-
Improving care for patients with ARDS, pneumonia, and sepsis
This study is all about improving care for people with serious lung issues like ARDS, pneumonia, and sepsis by gathering and analyzing data from a diverse group of patients, so we can better understand these conditions and find the best treatments for everyone.
-
Understanding the recovery patterns of patients with ARDS, pneumonia, and sepsis
This study is looking for people who have had serious breathing problems, like ARDS, pneumonia, or sepsis, to learn more about their recovery and find ways to better predict and improve their health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.