Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next year.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11087677 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular differences in patients suffering from Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis. By enrolling 1,000 participants across four clinical sites in California, the study aims to collect extensive clinical data and biological samples to identify distinct molecular phenotypes. Participants will be followed up at 3, 6, and 12 months to assess their recovery and health outcomes. The research utilizes advanced techniques like metagenomic sequencing to analyze the biological factors contributing to these critical conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing ARDS, pneumonia, or sepsis.
Not a fit: Patients with chronic respiratory conditions or those not currently experiencing ARDS, pneumonia, or sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with ARDS, pneumonia, and sepsis.
How similar studies have performed: Previous research has shown promise in identifying molecular phenotypes in ARDS and utilizing metagenomic sequencing, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Calfee, Carolyn — University of California, San Francisco
- Study coordinator: Calfee, Carolyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.