Eicosanoids and Heart Risk in Chronic Kidney Disease
Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11181170
This research explores how natural body chemicals called eicosanoids might connect chronic kidney disease with heart problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11181170 on ClinicalTrials.gov |
What this research studies
Many people with chronic kidney disease (CKD) face a higher risk of heart and blood vessel issues, and current treatments often don't work as well for them. We believe that inflammation throughout the body plays a key role in these heart problems for CKD patients. This project looks at specific natural chemicals called eicosanoids, which come from fats in our diet and can either cause or reduce inflammation. By using advanced lab techniques, we aim to understand how these eicosanoids are out of balance in people with CKD and how that imbalance contributes to both kidney disease getting worse and heart complications.
Who could benefit from this research
Good fit: Ideal candidates would be adults aged 21 and older who have chronic kidney disease and are at risk for cardiovascular complications.
Not a fit: Patients without chronic kidney disease or those not at risk for related cardiovascular issues would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict and prevent heart disease in people living with chronic kidney disease.
How similar studies have performed: While the link between inflammation and kidney disease is known, this specific focus on eicosanoid pathways in CKD-related cardiovascular risk is a novel approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, SUSAN — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: CHENG, SUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.