Eicosanoids and Heart Risk in Chronic Kidney Disease
Official title: Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
Funded at Cedars-Sinai Medical Center · NIH-11181170 · Data updated 2026-11-12
This research explores how natural body chemicals called eicosanoids might connect chronic kidney disease with heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $892,433 |
| NIH project number | 5R01DK141162-02 |
| Project ID | NIH-11181170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be adults aged 21 and older who have chronic kidney disease and are at risk for cardiovascular complications.
✕Less likely to help
Patients without chronic kidney disease or those not at risk for related cardiovascular issues would not directly benefit from this specific research.
What this research studies
Many people with chronic kidney disease (CKD) face a higher risk of heart and blood vessel issues, and current treatments often don't work as well for them. We believe that inflammation throughout the body plays a key role in these heart problems for CKD patients. This project looks at specific natural chemicals called eicosanoids, which come from fats in our diet and can either cause or reduce inflammation. By using advanced lab techniques, we aim to understand how these eicosanoids are out of balance in people with CKD and how that imbalance contributes to both kidney disease getting worse and heart complications.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict and prevent heart disease in people living with chronic kidney disease.
How similar studies have gone: While the link between inflammation and kidney disease is known, this specific focus on eicosanoid pathways in CKD-related cardiovascular risk is a novel approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Cheng, Susan — Cedars-Sinai Medical Center
- Study coordinator: Cheng, Susan
Related research
Other NIH-funded projects on the same topics.
-
Eicosanoids and kidney disease link to heart risks
This grant explores how tiny fat-derived molecules (eicosanoids) influence kidney disease and heart risk in adults.
-
Investigating how eicosanoids affect kidney disease and heart health
This study is looking at how certain tiny molecules from fats affect kidney disease and heart health in people with chronic kidney disease, hoping to find new ways to help manage these conditions better.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.