Investigating how eicosanoids affect kidney disease and heart health
Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
This study is looking at how certain tiny molecules from fats affect kidney disease and heart health in people with chronic kidney disease, hoping to find new ways to help manage these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11000030 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of eicosanoids, which are small molecules derived from fatty acids, in the progression of chronic kidney disease (CKD) and its associated cardiovascular risks. By examining how these bioactive lipids influence inflammation and cardiovascular outcomes in patients with CKD, the study aims to identify potential new therapeutic targets. Advanced techniques like mass spectrometry will be used to measure various eicosanoid levels in patients, providing insights into their relationship with kidney function and heart health. The findings could lead to better management strategies for patients suffering from CKD and related cardiovascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with chronic kidney disease.
Not a fit: Patients without chronic kidney disease or those with acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce cardiovascular risks for patients with chronic kidney disease.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve outcomes in chronic diseases, suggesting potential success for this approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cheng, Susan — Cedars-Sinai Medical Center
- Study coordinator: Cheng, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.