Investigating how eicosanoids affect kidney disease and heart health
Official title: Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
Funded at Cedars-Sinai Medical Center · NIH-11000030 · Data updated 2026-11-12
This study is looking at how certain tiny molecules from fats affect kidney disease and heart health in people with chronic kidney disease, hoping to find new ways to help manage these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $892,433 |
| NIH project number | 1R01DK141162-01 |
| Project ID | NIH-11000030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with chronic kidney disease.
✕Less likely to help
Patients without chronic kidney disease or those with acute kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of eicosanoids, which are small molecules derived from fatty acids, in the progression of chronic kidney disease (CKD) and its associated cardiovascular risks. By examining how these bioactive lipids influence inflammation and cardiovascular outcomes in patients with CKD, the study aims to identify potential new therapeutic targets. Advanced techniques like mass spectrometry will be used to measure various eicosanoid levels in patients, providing insights into their relationship with kidney function and heart health. The findings could lead to better management strategies for patients suffering from CKD and related cardiovascular issues.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce cardiovascular risks for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can improve outcomes in chronic diseases, suggesting potential success for this approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Cheng, Susan — Cedars-Sinai Medical Center
- Study coordinator: Cheng, Susan
Related research
Other NIH-funded projects on the same topics.
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Eicosanoids and kidney disease link to heart risks
This grant explores how tiny fat-derived molecules (eicosanoids) influence kidney disease and heart risk in adults.
-
Eicosanoids and Heart Risk in Chronic Kidney Disease
This research explores how natural body chemicals called eicosanoids might connect chronic kidney disease with heart problems.
-
Personalized CKD-MBD care using systems biology and AI
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.