Fasting-mimicking diet and cancer stem cells in Wilms tumor
Official title: Fasting mimicking diet and cancer stem cells in Wilms tumor
Funded at Children's Hospital of Los Angeles · NIH-11434150 · Data updated 2026-11-12
Aiming to see if a fasting-mimicking diet can boost cancer-killing treatment while protecting healthy cells in children with Wilms tumor.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $739,756 |
| NIH project number | 1R01CA317076-01 |
| Project ID | NIH-11434150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pediatric Wilms tumor patients, particularly those with relapsed or high-risk disease, may benefit from future translational steps.
✕Less likely to help
Patients with Wilms tumor who do not respond to the proposed approach or who are not eligible for related trials may not benefit.
What this research studies
This research will study how cycles of a fasting-mimicking diet affect Wilms tumor cells, especially cancer stem cells, in the lab and in animal models. The team will look at how the diet may lower growth signals in tumor cells and reduce their ability to renew, potentially making chemotherapy more effective and less toxic. The project builds on prior lab findings that FMD can alter IGF1/IGFR1, PI3K/AKT, and mTOR pathways relevant to tumor behavior. If findings translate, this could inform new dietary strategies to complement standard therapy in high-risk pediatric Wilms tumor patients.
Why it matters
Potential benefit: If successful, the approach could improve treatment effectiveness while reducing side effects for children with Wilms tumor.
How similar studies have gone: Preclinical data suggest that fasting-m mimicking diets can enhance chemotherapy and protect normal cells, with ongoing exploration in pediatric cancers.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Perin, Laura — Children's Hospital of Los Angeles
- Study coordinator: Perin, Laura
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.