Investigating the role of WT1 in a specific type of kidney cancer in children
WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor
This study is looking at how certain gene changes in kids with Wilms tumor, a type of kidney cancer, might affect how the cancer grows and responds to treatment, with the goal of finding better ways to help those who are at higher risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11003706 on NIH RePORTER |
What this research studies
This research focuses on Wilms tumor, the most common kidney cancer in children, particularly in high-risk patients who often face poor outcomes. The study aims to understand how mutations in the WT1 and TP53 genes affect tumor behavior and treatment resistance. By exploring the relationship between these mutations, the researchers hope to identify new therapeutic vulnerabilities that could lead to more effective treatments for anaplastic Wilms tumor. The approach involves testing the hypothesis that the loss of function in WT1 and TP53 mutations can be lethal to cancer cells, potentially leading to innovative treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Wilms tumor, particularly those exhibiting high-risk features such as diffuse anaplasia.
Not a fit: Patients with Wilms tumor who do not have mutations in the WT1 or TP53 genes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve outcomes for children with anaplastic Wilms tumor.
How similar studies have performed: Previous research has shown that targeting specific genetic mutations in tumors can lead to successful treatment strategies, suggesting that this approach may also yield promising results.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Murphy, Andrew J — St. Jude Children's Research Hospital
- Study coordinator: Murphy, Andrew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.