Investigating how mutations in a specific gene affect kidney development
Wilms tumor 1 (Wt1) mutation reveals mechanisms of cell lineage crosstalk in the developing kidney
This study is looking at how changes in a specific gene called Wt1 affect the way kidney cells work together during development, which could help us understand kidney formation and problems that might arise, and it's designed for researchers who want to learn more about this process.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10841677 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and molecular mechanisms that regulate kidney development, particularly how mutations in the Wilms tumor 1 (Wt1) gene influence interactions between different cell types in the developing kidney. The project involves detailed training and mentorship for the investigator, who will employ advanced techniques in bioinformatics and in-vitro studies to explore how Wt1 mutations affect nephron progenitor cells and their communication with surrounding stromal cells. By examining these cellular interactions, the research aims to uncover the underlying processes that contribute to kidney formation and potential abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting kidney development, particularly those related to Wilms tumor.
Not a fit: Patients without genetic mutations impacting kidney development or those with fully developed kidneys may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into kidney development and potential therapeutic strategies for kidney-related disorders.
How similar studies have performed: Previous research has shown success in understanding kidney development through genetic studies, making this approach promising yet still advancing the field.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Drake, Keri Anne — Ut Southwestern Medical Center
- Study coordinator: Drake, Keri Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.