Condition

Viral Infection clinical trials and research

• 11Clinical trials
• 78NIH research projects
• 3Countries

Newest Viral Infection clinical trials

All recruiting trials (11)

• Biomarkers linked to congenital CMV using newborn blood spots

  Researchers will test protein and RNA markers in dried blood spots from newborns to see if they can identify congenital CMV sequelae early.

  Recruiting at 2 sites Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT07635368

• Investigating how cold viruses affect bronchiectasis exacerbations

  This study is trying to see if cold viruses make symptoms worse for people with bronchiectasis compared to healthy individuals.

  Recruiting Imperial College London · London · NCT06931002

• Controlled exposure to a viral mimic for studying lung immune responses

  This study tests how people with asthma and healthy volunteers respond to a safe viral mimic to help understand and improve treatments for lung inflammation and asthma.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge, Cambridgeshire · NCT06488118

• HEPA air cleaners in inner-city elementary school classrooms

  This trial will test whether placing HEPA air cleaners in elementary classrooms lowers airborne virus levels and reduces infections among students, teachers, and household members.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05953233

• Effects of mouthrinse on oral and gut bacteria and viruses

  This study is testing how two popular mouthwashes affect the bacteria and viruses in your mouth and gut over six months.

  Recruiting University of California, Irvine · Irvine, California · NCT05603650

• T-cell therapy for chronic norovirus in immunocompromised patients

  This study is testing a new T-cell therapy for people with chronic norovirus infections who have weakened immune systems to see if it's safe for them.

  Recruiting at 3 sites Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 2 other locations · NCT04691622

• Using donor-derived T-cells to fight viral infections after stem cell transplant

  This study is testing whether using special immune cells from donors can help prevent or treat viral infections in people who have had a stem cell transplant.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT04230356

• Using donor-derived T-cells to treat BK infections in patients with weakened immune systems

  This study is testing if special immune cells made from donors can help children and young adults with weak immune systems get rid of stubborn BK infections after a stem cell transplant.

  Recruiting at 7 sites Phase 1/2 New York Medical College · San Francisco, California and 6 other locations · NCT04197596

• Using virus-specific T cells to treat infections after stem cell transplants

  This study is testing whether giving special immune cells from a donor can help patients who had a stem cell transplant fight off viral infections.

  Recruiting at 2 sites Phase 1 Baylor College of Medicine · Houston, Texas and 1 other locations · NCT04013802

• Infusion of donor-derived T-cells for viral infections in immunocompromised patients

  This study is testing whether T-cells from donors can help children with weakened immune systems fight off viral infections like EBV, CMV, and ADV after they have had stem cell transplants.

  Recruiting at 3 sites Phase 2 Children's Hospital Medical Center, Cincinnati · Akron, Ohio and 3 other locations · NCT02532452

• Using donor-derived T-cells to treat viral infections after stem cell transplants

  This study is testing whether T-cells from stem cell donors can help patients who have infections after their transplants fight off those viruses.

  Recruiting at 2 sites Phase 1/2 Children's Hospital Medical Center, Cincinnati · Akron, Ohio and 2 other locations · NCT02048332

NIH-funded research (newest 40 of 78)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Amyloid and HIV: How aging with HIV shapes Alzheimer’s disease at the cellular level

  Researchers are studying how aging people with HIV accumulate Alzheimer’s–related brain changes, to understand who might benefit from future therapies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11470035

• Placental responses to maternal viral infection shape sex-specific offspring immunity

  A mother’s viral infection during pregnancy can change how her baby’s immune system develops, potentially making some babies more prone to infections after birth.

  NIH research Wayne State University · Detroit, United States · NIH-11453155

• Gut bacteria and lung immune cells shape viral lung infections

  A study explores how gut microbes affect lung immune cells and severity of respiratory viral infections to identify potential ways to reduce illness.

  NIH research Georgia State University · Atlanta, United States · NIH-11449351

• Restoring helper CD4 T cells to help control chronic viral infections

  A research project tests a strategy to revive CD4 Th1 helper T cells to better control chronic viral infections like HIV and hepatitis B/C in people who need improved immune control.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11449036

• Screening small medicines to block RSV in baby and adult airway cells

  A small study tests whether certain drugs can block age-related signals in respiratory cells to stop RSV infection in infants and young children.

  NIH research Washington University · Saint Louis, United States · NIH-11448608

• Immune drivers of long-term lung damage after viral infection

  Researchers are studying why some people’s lungs stay damaged after severe viral infections like COVID-19 and how to stop this scarring from getting worse.

  NIH research University of Virginia · Charlottesville, United States · NIH-11445731

• Immune-driven lung repair after early-life viral lung infections

  This grant studies how young children’s lungs repair themselves after a viral lung infection and what helps or hinders healing.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11425478

• Stem-like CD8 T cells to boost antiviral immunity in chronic viral infection

  A research project aims to harness a special stem-like subset of CD8 T cells to improve immune responses against chronic viruses like HIV, HBV, and HCV.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11396316

• How a mother’s infection during pregnancy shapes baby’s immune cells

  A mother’s infection or inflammation during pregnancy may change how a baby’s immune system develops, especially a special type of immune cell called γδ T cells.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11391288

• Mitigating Viral Cytokine Storm by Stabilizing CIC Transcriptional Repression

  A research project at the University of Iowa aims to see if keeping a specific gene-repressor complex intact can calm overactive immune responses during severe respiratory viral infections.

  NIH research University of Iowa · Iowa City, United States · NIH-11391274

• Innate immunity and herpes-related retinal blindness

  This grant explores how the eye’s first-line immune defenses respond to herpes viruses that can cause sudden, painful retinal damage and vision loss, with aims to protect sight.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11391017

• How persistent viral parts in the lungs may drive long-term inflammation after respiratory infections

  This grant looks at why some people have lasting lung inflammation after respiratory viruses and how the body’s own immune cells keep the damage going, with the aim of finding broadly useful treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11387794

• T Cell Exhaustion and CD4 Help in Chronic Viral Infection

  Researchers are studying how CD8+ T cells become worn out during long-lasting infections and how CD4+ T cells help restore their fight against viruses.

  NIH research Northwestern University · Chicago, United States · NIH-11387651

• Molecular links between metabolism and viral infection in latent and active herpesvirus life cycles

  This grant studies how viruses change cellular metabolism during latent and active infection to understand what keeps cells alive and infected.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11384756

• Epigenetic programming of CD4+ T cell function during chronic viral infection

  Researchers are studying how a specific type of immune cell called CD4+ T cells changes at the DNA level during long-lasting viral infections, with the aim of improving vaccines and therapies.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11384251

• Understanding why some infected cells succeed and others fail to spread a virus

  A researcher-led project will study how individual cells decide to stop or continue viral infection, which could help develop smarter antiviral therapies.

  NIH research University of California-Irvine · Irvine, United States · NIH-11383422

• Understanding how different tissues and cell types respond to acute and chronic viral infections

  Researchers are studying why some viruses cause long-lasting infections by looking at how various human tissues and their cells react to viruses at the molecular level.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11378308

• Local translation in airway cells during viral infection

  A study in adults looks at how airway multiciliated cells make and locate proteins during viral infections to understand why infections can cause severe lung problems.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11377278

• How the immune protein RIG-I may cause glaucoma and change eye responses to viruses

  This project looks at whether changes in the immune protein RIG-I cause early glaucoma and make the eye respond worse to viral infections in people with inherited forms of glaucoma.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11372147

• Impact of high salt diet on CD8 T cell responses to acute viral infection

  A study to see how a high-salt diet affects how CD8 T cells respond during an acute viral infection.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11366613

• How vaccines work for people with solid organ transplants

  This project looks at how vaccines protect people with solid organ transplants from respiratory viruses like COVID-19, flu, and RSV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11353798

• How early asthma risk and infant RSV infection shape airway cells and future infections

  This project looks at how being at risk for asthma and early RSV infection might change airway lining cells in babies and how they respond to later viruses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11353465

• Understanding how innate immunity affects viral infections across mammals

  Researchers at the University of Minnesota are studying how our body's first-line defenses interact with viruses across different mammal species to learn why some viruses jump between species and how we might better protect people.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11349984

• How COVID-19 Infection Might Accelerate Lewy Pathology and Dementia

  This NIH grant explores how COVID-19 could influence brain changes linked to dementia, focusing on people affected by Alzheimer's disease and related dementias.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11344660

• Immune drivers of long-term lung damage after viral infection

  A team at Cedars-Sinai is studying why some people develop lasting breathing problems and lung scarring after severe viral infections.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11332091

• 3D human airway models to better understand lung immune responses

  This project builds more realistic 3D lab-grown human lung tissues to help researchers learn how lungs and immune cells react to viruses, which could help people with respiratory infections.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11330399

• How aging changes the lung's defenses against viruses

  The team is looking at how aging lung cells change local immune defenses against respiratory viruses, with a focus on people over 65.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11330386

• Tracking how viruses move inside real tissues

  Researchers are developing a high-speed way to watch individual viruses move deep inside tissues to better understand how infections begin.

  NIH research Duke University · Durham, United States · NIH-11328790

• Maternal inflammation and epigenetics linked to autism in kids

  A study following children to understand how inflammation during pregnancy and epigenetic changes might contribute to autism in some kids.

  NIH research Institute for Basic Res in Dev Disabil · Staten Island, United States · NIH-11316991

• Inhaled live probiotic therapy for influenza infection

  A new inhaled probiotic treatment is being studied to help people with influenza-related respiratory illness by using live bacteria to modulate lung inflammation and viral effects.

  NIH research Alveolus Bio, INC. · Birmingham, United States · NIH-11314239

• How Pim1 helps 'killer' CD8 T cells keep fighting long-term viral infections

  Researchers are looking at whether the protein Pim1 helps CD8 'killer' T cells stay active and avoid exhaustion during chronic viral infections.

  NIH research Northwestern University · Chicago, United States · NIH-11230250

• Transitional dendritic cells and their role in viral infections

  Aims to understand a new type of immune cell called transitional dendritic cells and how they help fight viruses in humans and mice.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11228084

• How the body's first line of defense fights viruses like coronaviruses

  Researchers study how innate immune sensors detect viruses and trigger antiviral responses, including how coronaviruses evade this defense, with potential implications for therapies.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11210633

• How infections or inflammation during pregnancy can change a baby's immune cells

  This project looks at whether a mother's infection or inflammation while pregnant changes how a baby's T cells develop and could affect health later on.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11184505

• Herpesvirus-linked Alzheimer's changes in the brain

  Researchers are looking at whether common brain herpesviruses cause Alzheimer's-related changes in human brain cells to help people at risk for or living with Alzheimer's.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11173886

• Finding how viruses act in the very early stages of infection using data and computation

  This project creates computer tools that use single-cell data and gene‑editing experiments to find which genes control early viral replication and host responses, aiming to help people at risk from viruses like coronaviruses.

  NIH research Yale University · New Haven, United States · NIH-11159450

• How differences between individual cells shape viral infections

  This project looks at why some infected cells stop a virus while others produce many copies, using herpes virus models to help people with viral infections.

  NIH research University of California-Irvine · Irvine, United States · NIH-11143067

• Understanding the Body's Response to Acute and Chronic Viral Infections

  This project explores how different cells and organs in our body fight off acute and long-lasting viral infections.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11142627

• Understanding Immunity and Viruses in Asthma

  This project explores how our body's natural defenses respond to common viruses in people with asthma.

  NIH research University of Arizona · Tucson, United States · NIH-11132917

• Tracking Viruses in 3D to Understand Infections

  This research uses a new 3D tracking method to watch how viruses infect cells deep within tissues, like those in the lungs or gut.

  NIH research Duke University · Durham, United States · NIH-11120871

Related topics

Quick answers

How many Viral Infection clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (8 trials), United Kingdom (2 trials), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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