Immune-driven lung repair after early-life viral lung infections
Official title: Immune-mediated lung repair following early life respiratory viral infection
Funded at University of Pittsburgh at Pittsburgh · NIH-11425478 · Data updated 2026-11-12
This grant studies how young children’s lungs repair themselves after a viral lung infection and what helps or hinders healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 7, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $772,932 |
| NIH project number | 1R01HL187347-01 |
| Project ID | NIH-11425478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children who experience viral lower respiratory tract infections in early life and who have or are at risk for long-term lung changes.
✕Less likely to help
Children without early-life viral LRTIs or who have unaffected lungs may see little direct benefit.
What this research studies
Researchers will use a mouse model of neonatal viral lung infection to understand how early-life infections affect lung development and identify biomarkers and potential therapies to improve long-term lung outcomes. The work focuses on lung repair pathways, especially cells involved in regenerating alveolar tissue, and how age influences these processes. The project aims to translate findings toward better prevention or treatment strategies for children who suffer from viral LRTIs.
Why it matters
Potential benefit: If successful, the research could lead to biomarkers for risk of poor lung outcomes and new therapies to improve lung repair after early-life viral infections.
How similar studies have gone: Previous models have shown age-related differences in repair pathways, suggesting potential for targeted therapies in infants.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Eddens, Taylor John — University of Pittsburgh at Pittsburgh
- Study coordinator: Eddens, Taylor John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.