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Rectal Cancer Patients clinical trials and research

• 17Clinical trials
• 3NIH research projects
• 1New in 30 days
• 7Countries

Newest Rectal Cancer Patients clinical trials

All recruiting trials (17)

• NeoCSR-Omics: CAPOX and Serplulimab Before or After Short-Course RT in Locally Advanced Rectal Cancer

  This trial tests whether giving CAPOX chemotherapy with the PD-1 blocker serplulimab before or after short-course radiotherapy helps people with locally advanced rectal cancer achieve complete clinical or pathological responses.

  Recruiting Phase 2 Chongqing University Cancer Hospital · Chongqing, Chongqing Municipality · NCT07898865

• PPISR for low- to mid-rectal cancer with anus-sparing aim

  This study tests whether Precision Partial Intersphincteric Resection can be safely used to remove certain rectal cancers while preserving the anus.

  Recruiting First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07849023

• BT-001 plus pembrolizumab for localized pMMR rectal cancer

  This early-phase trial tests whether adding the oncolytic virus BT-001 to pembrolizumab is safe and tolerable for adults with localized pMMR rectal cancer prior to definitive surgery.

  Recruiting Phase 1 Bispebjerg Hospital · Copenhagen, Captial Region · NCT07687875

• Transanal vs Robotic Total Mesorectal Excision for Low Rectal Cancer

  This study tests whether taTME or robot-assisted TME works better for low rectal cancer patients and whether one method leads to fewer complications or conversions.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT07651553

• Gynecological and sexual aftereffects following rectal cancer treatment

  This work will test whether gynecological anatomical changes after rectal cancer treatment are linked to ongoing sexual problems in women aged 18–60 who are in remission.

  Recruiting University Hospital, Rouen · Rouen · NCT07389863

• Selective completion total mesorectal excision guided by intra-operative frozen pathology after local excision for low rectal cancer

  This trial tests whether using an immediate frozen-pathology result after local excision to decide if a full total mesorectal excision is needed can keep cancer controlled for adults with low rectal cancer who had a near-complete or small residual response to preoperative chemoradiotherapy.

  Recruiting Sun Yat-sen University · Guangzhou, Guanggong · NCT07337811

• Radiotherapy Plus CAPOX and Iparomlimab and Tuvonralimab as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

  This trial tests whether adding immunotherapy with chemotherapy and radiotherapy before surgery can improve how well locally advanced rectal cancer responds.

  Recruiting Phase 2 Zhongnan Hospital · Wuhan, Hubei · NCT07291401

• Short-course pelvic radiotherapy followed by CAPOX (capecitabine + oxaliplatin) and bevacizumab, with or without PD‑1 immunotherapy, for locally advanced rectal cancer.

  This trial tests whether adding a PD‑1 immunotherapy to short-course radiotherapy followed by CAPOX and bevacizumab helps adults with locally advanced rectal cancer get a higher complete response rate and fewer distant metastases.

  Recruiting Phase 2 Ruijin Hospital · Shanghai · NCT07198165

• Neoadjuvant chemoradiotherapy versus primary surgery with blood-based tumor cell monitoring for rectal cancer

  We will test whether giving long-course chemoradiotherapy before surgery versus having surgery first changes circulating tumor cells in people with stage II–III rectal cancer who have no circumferential resection margin involvement.

  Recruiting at 4 sites University Hospital Ostrava · Olomouc and 3 other locations · NCT07194616

• Neoadjuvant mFOLFOX with Citrus Flavonoid Tablets for YWHAB-High Locally Advanced Rectal Cancer

  In people with locally advanced rectal cancer who have high YWHAB expression, this study tests whether adding citrus flavonoid tablets to a standard mFOLFOX neoadjuvant regimen helps shrink tumors before surgery.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07176182

• How multimodal treatment affects tumor cells in the blood of people with rectal cancer.

  This study will see if multimodal treatment changes levels of circulating tumor cells in people with rectal cancer.

  Recruiting The Institute of Molecular and Translational Medicine, Czech Republic · Ostrava · NCT07112937

• Combining radiotherapy with immunotherapy and chemotherapy for rectal cancer treatment

  This study is testing if a new combination of short-term radiotherapy, immunotherapy, and chemotherapy can help people with locally advanced rectal cancer do better before surgery.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06911684

• Neoadjuvant treatment for rectal cancer using TAS-102 or capecitabine

  This study is testing if a new oral cancer medication called TAS-102 works better than the standard treatment, capecitabine, for people with locally advanced rectal cancer before surgery.

  Recruiting Phase 3 Shandong Cancer Hospital and Institute · Jinan, Shandong · NCT06850090

• Comparing single-port and multi-port robotic surgery for rectal cancer

  This study is testing whether single-port robotic surgery is safer and helps patients recover faster than multi-port robotic surgery for people with rectal cancer.

  Recruiting Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Chongqing · NCT06824688

• Evaluating a new imaging technique for rectal cancer staging

  This study is testing a new imaging technique to see if it can help doctors better detect the spread of rectal cancer to nearby lymph nodes, which could lead to more effective treatments for patients.

  Recruiting Phase 2 NanoEcho AB · Uppsala · NCT06693375

• Chemotherapy plus PD-1 immunotherapy before surgery for locally advanced rectal cancer (CONTROL-01)

  This trial will try three cycles of CAPOX chemotherapy together with the PD-1 drug tislelizumab before surgery in adults with locally advanced rectal cancer to see if it is safe and helps improve tumor control.

  Recruiting Phase 2 The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT06647680

• Comparing two radiation treatment approaches for stage II rectal cancer

  This study is testing two different ways of giving radiation treatment to see which one helps older patients with stage II rectal cancer better avoid surgery and keep their rectum.

  Recruiting at 4 sites Phase 2/3 Sir Mortimer B. Davis - Jewish General Hospital · Dallas, Texas and 3 other locations · NCT03051464

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Time-restricted eating during rectal cancer treatment to reduce toxicity and improve outcomes

  A clinical trial tests whether eating only within a set time window during cancer treatment can reduce side effects and help treatments work better for rectal cancer patients.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11411217

• ColoSeal device to avoid temporary ostomies after rectal cancer surgery

  This project tests a minimally invasive device designed to help many rectal cancer patients avoid having a temporary ostomy after surgery.

  NIH research Averto Medical INC · Fremont, UNITED STATES · NIH-11195700

• New device to reduce the need for temporary ostomies in rectal cancer patients

  This study is testing a new, less invasive device that could help people with rectal cancer avoid the need for temporary ostomies, making their treatment easier and improving their quality of life.

  NIH research Savage Medical · Belmont, United States · NIH-11007069

Related topics

Quick answers

How many Rectal Cancer Patients clinical trials are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (11 trials), Czechia (2 trials), Denmark (1 trial), France (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1: 1, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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