Condition

Rectal Adenocarcinoma clinical trials and research

• 25Clinical trials
• 33Countries

Newest Rectal Adenocarcinoma clinical trials

All recruiting trials (25)

• Neoadjuvant Radiotherapy Before Surgery for Locally Advanced Proximal Rectal Cancer

  This study tests whether giving radiotherapy before surgery reduces cancer return in people with locally advanced proximal rectal cancer.

  Recruiting Istanbul University · Istanbul · NCT07802197

• Short-course radiotherapy followed by PD-1 inhibitor and FOLFOX vs standard chemoradiotherapy for high‑risk locally advanced lower rectal cancer

  This trial tests whether giving a short course of radiotherapy followed by a PD-1 inhibitor and FOLFOX can be better than the usual long-course chemoradiotherapy for adults with high‑risk, locally advanced, pMMR/MSS lower rectal cancer.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou · NCT07669220

• Short-course radiotherapy plus intensified chemotherapy and targeted therapy with immunotherapy for high-risk rectal cancer

  This trial tests whether adding targeted therapy and a PD-1 inhibitor to a short course of radiotherapy and standard chemotherapy helps high-risk pMMR/MSS rectal cancer patients, compared with the same radiotherapy and chemotherapy alone.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07549399

• First-line trastuzumab-deruxtecan with capecitabine and bevacizumab for HER2-positive metastatic colorectal cancer

  This trial tests whether giving trastuzumab-deruxtecan together with capecitabine and bevacizumab as first treatment helps people with HER2-positive metastatic or unresectable colorectal cancer shrink tumors and respond better.

  Recruiting at 28 sites Phase 2 Gruppo Oncologico del Nord-Ovest · Lyon and 27 other locations · NCT07407465

• Long-term follow-up of bowel function (LARS) after rectal cancer surgery and neoadjuvant therapy

  This project will see how bowel symptoms (LARS) change over time after sphincter-preserving rectal cancer surgery and whether different neoadjuvant treatment schedules affect those symptoms.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT07339904

• Rectal brachytherapy boost to try to avoid surgery for low-lying residual rectal cancer after total neoadjuvant therapy

  This trial will try focal internal radiation (rectal brachytherapy) for people with low-lying residual rectal adenocarcinoma after total neoadjuvant therapy to see if it can produce complete responses and avoid surgery.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado and 2 other locations · NCT07292298

• Short-course pelvic radiotherapy followed by CAPOX (capecitabine + oxaliplatin) and bevacizumab, with or without PD‑1 immunotherapy, for locally advanced rectal cancer.

  This trial tests whether adding a PD‑1 immunotherapy to short-course radiotherapy followed by CAPOX and bevacizumab helps adults with locally advanced rectal cancer get a higher complete response rate and fewer distant metastases.

  Recruiting Phase 2 Ruijin Hospital · Shanghai · NCT07198165

• Family genetics: who shares test results with relatives

  This study tests whether letting patients share genetic results with their relatives is as good as doctors sharing the results to help first-degree relatives get genetic testing for hereditary cancer risk.

  Recruiting at 362 sites Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 364 other locations · NCT07143487

• Calderasib plus cetuximab and chemotherapy for KRAS G12C colorectal cancer

  This trial will test whether adding calderasib and cetuximab to mFOLFOX6 helps people with unresectable locally advanced or metastatic colorectal cancer that has a KRAS G12C mutation live longer without their cancer growing.

  Recruiting at 244 sites Phase 3 Merck Sharp & Dohme LLC · Phoenix, Arizona and 244 other locations · NCT06997497

• Personalized treatment approach for rectal adenocarcinoma

  This study is testing a personalized treatment plan for people with rectal adenocarcinoma to see if a mix of less invasive surgeries and special therapies can improve their quality of life and reduce the chance of cancer coming back.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Turin · NCT06952101

• Increasing radiotherapy doses for rectal cancer treatment

  This study tests if giving a higher dose of radiation can help people with advanced rectal cancer avoid surgery by seeing if it leads to better treatment results.

  Recruiting Royal Marsden NHS Foundation Trust · Sutton, Surrey · NCT06854679

• Neoadjuvant FOLFOX with botensilimab and balstilimab for localized rectal cancer

  This test tries whether giving FOLFOX chemotherapy together with the immune drugs botensilimab and balstilimab before surgery helps people with localized rectal cancer achieve a complete clinical response.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06780787

• Database for managing rectal cancer patients with a watch-and-wait approach

  This study is trying to gather information from rectal cancer patients in Asia who are closely monitored after treatment to see if the watch-and-wait approach is safe and effective for them.

  Recruiting Tata Memorial Centre · Mumbai, Maharashtra · NCT06631443

• Using metronidazole to improve treatment for rectal cancer

  This study is testing if adding metronidazole to standard treatment can help people with rectal cancer by reducing harmful bacteria in their tumors and improving their chances of survival.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06569368

• Nonoperative management of rectal cancer after neoadjuvant therapy

  This study is testing if people with rectal cancer who have a complete response to initial treatment can safely avoid surgery and still do well in terms of their health and quality of life.

  Recruiting at 13 sites Tampere University Hospital · Tallinn and 12 other locations · NCT06328361

• Combining short radiation with immunotherapy and chemotherapy for rectal cancer treatment

  This study is testing a new treatment for patients with a specific type of rectal cancer that combines short radiation, immunotherapy, and chemotherapy to see if it can help keep their organs and reduce the need for surgery.

  Recruiting Phase 2 Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06266832

• Combining Tucatinib and Trastuzumab for HER2 Positive Rectal Cancer

  This study is testing if combining two cancer drugs, tucatinib and trastuzumab, with standard chemotherapy can help people with HER2 positive rectal cancer have better treatment results.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05672524

• Using blood tests to improve treatment strategies for rectal cancer

  This study is testing if measuring tumor DNA in the blood can help doctors see how well treatments are working for people with stage II-III rectal cancer.

  Recruiting at 2 sites OHSU Knight Cancer Institute · Portland, Oregon and 1 other locations · NCT05081024

• Observing cancer recurrence using a blood test

  This study is testing a new blood test to see if it can help find out if cancer comes back in people who have been treated for early-stage solid tumors.

  Recruiting at 49 sites Guardant Health, Inc. · Birmingham, Alabama and 56 other locations · NCT05059444

• MRI-guided radiation therapy for rectal cancer organ preservation

  This study is testing a new type of MRI-guided radiation therapy for people with advanced rectal cancer to see if it can safely preserve their organs while treating the disease.

  Recruiting Phase 1 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT04808323

• Short course radiation therapy combined with chemotherapy for stage II-III rectal cancer

  This study is testing a new treatment plan that combines short radiation therapy with chemotherapy to see if it helps people with stage II-III rectal cancer feel better and have fewer problems after treatment.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT04703101

• Treatment for advanced solid tumors using PD-1 blockade and chemoradiotherapy

  This study is testing if a new drug combined with standard chemotherapy and radiation can help people with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting at 10 sites Phase 2 Memorial Sloan Kettering Cancer Center · Hartford, Connecticut and 9 other locations · NCT04165772

• Using MRI to Monitor Treatment Response in Rectal Cancer

  This study is testing if using special MRI scans can help doctors see how well treatment is working for patients with rectal cancer who are getting chemotherapy and radiation.

  Recruiting Institut Paoli-Calmettes · Los Angeles, California and 1 other locations · NCT03961776

• Monitoring and chemotherapy before surgery for stage II-III rectal cancer

  This study tests if monitoring and chemotherapy before surgery can help people with stage II-III rectal cancer keep their organs and improve their treatment choices.

  Recruiting Early Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03594630

• Evaluating quality of life after surgery for rectal cancer

  This study looks at how surgery for rectal cancer affects the quality of life for patients over time, comparing those who received radiation therapy to those who didn’t.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT02107105

Related topics

Quick answers

How many Rectal Adenocarcinoma clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 33 countries. The most sites are in United States (14 trials), China (5 trials), France (4 trials), Italy (4 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1: 2, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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