Condition

Rectal Cancer Stage III clinical trials and research

• 8Clinical trials
• 4Countries

Newest Rectal Cancer Stage III clinical trials

All recruiting trials (8)

• Neoadjuvant mFOLFOX with Citrus Flavonoid Tablets for YWHAB-High Locally Advanced Rectal Cancer

  In people with locally advanced rectal cancer who have high YWHAB expression, this study tests whether adding citrus flavonoid tablets to a standard mFOLFOX neoadjuvant regimen helps shrink tumors before surgery.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07176182

• Using bioabsorbable staples to improve surgery outcomes for rectal and lung cancer

  This study is testing if using special dissolvable staples during stomach, colorectal, and lung surgeries can help patients have fewer complications after their operations compared to regular staples.

  Recruiting Phase 3 Shanghai Cingularbio Co. Ltd · Shanghai · NCT06968221

• Meal timing during cancer treatment for Alaska Native and American Indian patients

  This test will see if an 8-hour time-restricted eating schedule during neoadjuvant or adjuvant therapy helps Alaska Native and American Indian adults with rectal or certain breast cancers.

  Recruiting Fred Hutchinson Cancer Center · Anchorage, Alaska · NCT06802172

• Monitoring blood markers to predict treatment response in rectal cancer

  This study is testing if measuring certain blood markers in patients with stage II and III rectal cancer can help predict how well they respond to treatment.

  Recruiting Gene Solutions · Ho Chi Minh City · NCT06589388

• Prehabilitation program for patients with rectal cancer

  This study is testing a prehabilitation program to see if it helps people with rectal cancer feel better before surgery compared to standard care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06565052

• Effects of Tislelizumab with Chemotherapy in Advanced Rectal Cancer

  This study is testing if adding a new drug called Tislelizumab to chemotherapy can help people with advanced rectal cancer have better outcomes before surgery.

  Recruiting Phase 2 First Affiliated Hospital of Guangxi Medical University · Nanning, Guangxi · NCT06254521

• UGT1A1-guided irinotecan therapy for advanced rectal cancer

  This study is testing if adjusting the dose of irinotecan based on a specific gene can help people with advanced rectal cancer do better with their treatment before surgery.

  Recruiting Phase 4 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT05148767

• Comparing two radiation treatment approaches for stage II rectal cancer

  This study is testing two different ways of giving radiation treatment to see which one helps older patients with stage II rectal cancer better avoid surgery and keep their rectum.

  Recruiting at 4 sites Phase 2/3 Sir Mortimer B. Davis - Jewish General Hospital · Dallas, Texas and 3 other locations · NCT03051464

Related topics

Quick answers

How many Rectal Cancer Stage III clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (4 trials), United States (3 trials), Vietnam (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 4: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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