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Locally Advanced Rectal Cancer (LARC) clinical trials and research

• 10Clinical trials
• 1New in 30 days
• 5Countries

Newest Locally Advanced Rectal Cancer (LARC) clinical trials

All recruiting trials (10)

• NeoCSR-Omics: CAPOX and Serplulimab Before or After Short-Course RT in Locally Advanced Rectal Cancer

  This trial tests whether giving CAPOX chemotherapy with the PD-1 blocker serplulimab before or after short-course radiotherapy helps people with locally advanced rectal cancer achieve complete clinical or pathological responses.

  Recruiting Phase 2 Chongqing University Cancer Hospital · Chongqing, Chongqing Municipality · NCT07898865

• Personalized blood ctDNA-MRD multi-omics test to predict neoadjuvant therapy response in rectal cancer

  This project will test whether a personalized blood-based ctDNA-MRD multi-omics test can predict how well neoadjuvant therapy works for people with locally advanced rectal cancer.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT07393048

• Short-course radiotherapy plus CAPOX chemotherapy with serplulimab and bevacizumab for mid-low MSS rectal cancer

  This trial will try short-course radiotherapy followed by CAPOX chemotherapy together with serplulimab and bevacizumab before surgery in people with mid-low MSS locally advanced rectal cancer to see if it is safe and shrinks tumors.

  Recruiting Phase 2 First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07347951

• Neoadjuvant dostarlimab for locally advanced dMMR/MSI‑H rectal cancer in routine practice

  This project will try neoadjuvant dostarlimab in adults with dMMR/MSI‑H stage II–III rectal cancer to see how well it works and how safe it is in real-world clinical care.

  Recruiting National Cancer Institute, Naples · Naples and 1 other locations · NCT07269249

• Optimizing immunotherapy with pre-surgery chemotherapy and radiation for locally advanced rectal cancer

  This trial will test whether adding the immunotherapy drug sintilimab to different timings and types of pre-surgery chemotherapy and radiotherapy helps people with locally advanced rectal cancer shrink tumors and preserve rectal function.

  Recruiting at 2 sites Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing and 1 other locations · NCT07040098

• Personalized long-course radiotherapy and chemotherapy, with or without immunotherapy, for locally advanced rectal cancer

  This study tests whether adding the immunotherapy drug serplulimab to personalized long-course radiotherapy and chemotherapy helps adults with locally advanced rectal cancer achieve complete tumor disappearance.

  Recruiting Phase 3 West China Hospital · Chengdu, Sichuan · NCT07020247

• Adding the immunotherapy drug tislelizumab to total neoadjuvant treatment for locally advanced rectal cancer

  This trial will test whether giving the immunotherapy drug tislelizumab together with total neoadjuvant treatment helps people with locally advanced rectal cancer avoid major surgery.

  Recruiting Phase 2 Rabin Medical Center · Mainz and 1 other locations · NCT06940388

• Short-course radiotherapy followed by CAPEOX with iparomlimab and tuvonralimab for resectable MSS/pMMR locally advanced rectal cancer

  This trial will test whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to short-course radiation and CAPEOX chemotherapy helps patients with resectable locally advanced MSS/pMMR rectal cancer keep their rectum and avoid major surgery.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06864013

• Optimizing patient selection for surgery in advanced rectal cancer

  This study is testing if a new way to remove leftover cancer tissue after treatment can help doctors choose the best surgery for patients with advanced rectal cancer who responded well to earlier therapy.

  Recruiting Centre Hospitalier Universitaire Saint Pierre · Brussels · NCT06761287

• Using PET/MRI to assess treatment effectiveness in advanced rectal cancer

  This study is testing whether advanced imaging techniques like PET/MRI can better show how well treatment is working for people with locally advanced rectal cancer before their surgery.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06653452

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Quick answers

How many Locally Advanced Rectal Cancer (LARC) clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (7 trials), Belgium (1 trial), Italy (1 trial), Germany (1 trial), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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