New device to reduce the need for temporary ostomies in rectal cancer patients
Official title: Safety and Efficacy Trial of the ColoSeal ICD System for the Treatment of Rectal Cancer Patients
Funded at Savage Medical · NIH-11007069 · Data updated 2026-11-12
This study is testing a new, less invasive device that could help people with rectal cancer avoid the need for temporary ostomies, making their treatment easier and improving their quality of life.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Savage Medical NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $838,162 |
| NIH project number | 1R44CA287615-01A1 |
| Project ID | NIH-11007069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with rectal cancer who are facing surgical treatment options.
✕Less likely to help
Patients who have already undergone permanent ostomy surgery or those with advanced rectal cancer may not benefit from this research.
What this research studies
This research investigates a new minimally-invasive medical device designed to replace the need for temporary ostomies in patients undergoing treatment for rectal cancer. The device aims to minimize the complications and negative impacts associated with traditional ostomy surgeries, which are often necessary for rectal cancer patients. By using this innovative technology, the goal is to allow the majority of patients to avoid the burdensome process of ostomy creation and reversal, thereby improving their quality of life during cancer treatment. The study will assess the safety and efficacy of this device in a clinical setting.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for rectal cancer patients by reducing the need for temporary ostomies.
How similar studies have gone: Similar approaches in minimizing surgical interventions for cancer patients have shown promise, but this specific device represents a novel solution.
Where this research is happening
-
Savage Medical
Belmont, United States Active
Researchers
- Principal investigator: Fong, Kenton Dodyan — Savage Medical
- Study coordinator: Fong, Kenton Dodyan
Related research
Other NIH-funded projects on the same topics.
-
Time-restricted eating during rectal cancer treatment to reduce toxicity and improve outcomes
A clinical trial tests whether eating only within a set time window during cancer treatment can reduce side effects and help treatments work better for rectal cancer patients.
-
ColoSeal device to avoid temporary ostomies after rectal cancer surgery
This project tests a minimally invasive device designed to help many rectal cancer patients avoid having a temporary ostomy after surgery.
-
Molecular Characterization of Radiation Effects in Rectal Cancer
A patient-facing platform study aims to link tissue changes, imaging, and the immune system during radiotherapy for rectal cancer to improve future treatments.
-
Immune System and Radiation in Rectal Cancer
This grant supports a small international study to understand how radiation therapy interacts with the immune system in rectal cancer by collecting tumor, blood, stool, and lymph node samples from patients before and after treatment.
-
Targeting tryptophan metabolism to improve rectal cancer treatment
This NIH grant is exploring a new way to help people with locally advanced rectal cancer by combining radiation with a drug that blocks a pathway our immune system uses to protect tumors.
-
Enhancing Rectal Cancer Immunotherapy with Radiation-Induced Senescence and PTPN2 Inhibition
This grant explores a combo approach using radiation and a targeted inhibitor to boost the body's immune attack on rectal cancer, aiming to preserve the organ and reduce long-term side effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.