Condition

Radiotherapy Side Effect clinical trials and research

• 35Clinical trials
• 16Countries

Newest Radiotherapy Side Effect clinical trials

All recruiting trials (35)

• Self‑manual lymph drainage for head and neck lymphedema

  This trial will test whether different intensities of self‑applied manual lymph drainage help people with head and neck lymphedema after radiotherapy for oropharyngeal cancer.

  Recruiting Lund University · Lund, Skåne County · NCT07215169

• Health-Oriented Protocol for Epidermal Radiodermatitis

  This study looks at how skin reactions from radiation therapy affect adults with head/neck or pelvic cancers and whether certain factors influence RID outcomes.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07129525

• Skipping the clinical target volume (CTV) around the primary tumor in limited-stage small cell lung cancer

  This trial tests whether giving chest radiotherapy that skips the usual extra margin around the main tumor is as effective and causes fewer side effects for people with limited-stage small cell lung cancer who have responded to initial chemotherapy.

  Recruiting at 2 sites Phase 3 Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07008716

• Curative chest re‑irradiation for thoracic cancers

  This project will try a standardized high‑dose re‑radiation approach for adults with recurrent or new thoracic cancers who previously received chest radiotherapy to see how well it controls disease and what toxicities occur.

  Recruiting University of Aarhus · Aarhus, Jutland · NCT06950073

• Radiotherapy for Head and Neck Cancer with Simultaneous Integrated Boost

  This study is testing a new type of radiation therapy for people with head and neck cancer to see if it helps them live longer and feel better while causing fewer side effects.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT06831903

• Comparing total neoadjuvant therapy with surgery for rectal cancer treatment

  This study is testing if rectal cancer patients who respond well to a new treatment can skip surgery and just be monitored to see how they do compared to those who have surgery right away.

  Recruiting Phase 2/3 National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos · Vilnius · NCT06758830

• Optimizing radiotherapy to protect thyroid function in nasopharyngeal carcinoma patients

  This study is testing whether a new way of giving radiotherapy can better protect the thyroid gland in patients with nasopharyngeal cancer compared to the standard treatment.

  Recruiting Phase 3 Jiangxi Provincial Cancer Hospital · Nanchang, Jiangxi · NCT06752239

• Limiting the radiation target area for glioblastoma to reduce treatment side effects

  This trial will test whether giving radiotherapy with a smaller margin around the tumor (10 mm instead of 15 mm) for adults with newly diagnosed glioblastoma can reduce side effects and improve quality of life.

  Recruiting at 18 sites Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Aalst and 22 other locations · NCT06719440

• Identifying genetic markers for radiation therapy response in breast cancer

  This study is trying to find genetic clues that can help predict how well breast cancer patients with ductal carcinoma in situ will respond to radiation therapy.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT06648148

• Hormone check-ups during the first five years after childhood brain radiation

  This program will test regular hormone checks for children and teens (ages 4–17) who had brain radiotherapy before age 16 to spot endocrine problems during the first five years after treatment.

  Recruiting at 3 sites University Hospital, Angers · Angers and 2 other locations · NCT06618703

• Partial breast irradiation for early-stage breast cancer

  This study is testing if a shorter 2-week radiation treatment for early-stage breast cancer is just as safe and effective as the standard 3-week treatment for women who have had breast-conserving surgery.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06615466

• Proton therapy for advanced cervical cancer

  This study is testing whether combining proton therapy with standard chemotherapy and brachytherapy can help people with advanced cervical cancer while reducing side effects.

  Recruiting Phase 2 University of Aarhus · Copenhagen · NCT06462378

• Evaluating lymphedema after targeted radiotherapy for breast cancer

  This study is testing if a new type of targeted radiation therapy can help prevent arm swelling in breast cancer patients after surgery.

  Recruiting European Institute of Oncology · Milan · NCT06321653

• Carbon ion radiotherapy for elderly patients with advanced lung cancer

  This study is testing if carbon ion radiotherapy can help older patients with advanced lung cancer feel better and live longer while looking at any side effects.

  Recruiting Phase 2 Shanghai Proton and Heavy Ion Center · Shanghai, Shanghai Municipality · NCT06311981

• Carbon ion radiotherapy for thymus tumors after surgery

  This study is testing if carbon ion radiotherapy combined with chemotherapy can help people with advanced thymus tumors feel better and live longer after surgery.

  Recruiting Phase 2 Shanghai Proton and Heavy Ion Center · Shanghai, Shanghai Municipality · NCT06311955

• Advanced radiotherapy for gynecological cancer patients

  This study looks at how advanced types of radiotherapy affect women with gynecological cancer to see how well they work and what side effects they might cause.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06306170

• Comparing dose painting with standard radiotherapy for head and neck cancer

  This study is testing a new way of giving radiation treatment for head and neck cancer to see if it causes fewer severe mouth sores than the standard method.

  Recruiting at 2 sites Oslo University Hospital · Bergen and 2 other locations · NCT06297902

• Using lithium to prevent cognitive decline after brain radiotherapy in children

  This study is testing if taking lithium can help prevent memory and thinking problems in children who have survived brain tumors and received radiation therapy.

  Recruiting Phase 2 Region Stockholm · Solna, Stockholm County and 1 other locations · NCT06051240

• Comparing two types of radiation therapy for prostate cancer treatment

  This study is testing whether a new type of radiation therapy for prostate cancer works better and is safer than a different method, while also looking at how well the treatment is tolerated by patients.

  Recruiting CHU de Quebec-Universite Laval · Québec · NCT05786742

• Radiotherapy options for low-risk breast cancer patients

  This study is testing a new type of radiation treatment for low-risk breast cancer patients to see if it can be safely given after surgery.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT05762900

• Combining Alectinib with Radiation Therapy for Advanced Lung Cancer with ALK Mutation

  This study is testing if combining alectinib with targeted radiation therapy can help people with advanced lung cancer that has an ALK mutation feel better and live longer.

  Recruiting Karolinska University Hospital · Stockholm · NCT05724004

• Stereotactic radiotherapy for centrally and ultra-centrally located lung tumors

  This study is testing a type of targeted radiation therapy for patients with lung tumors located in tricky spots to see how safe and effective it is.

  Recruiting at 5 sites Copenhagen University Hospital, Rigshospitalet · Aalborg and 5 other locations · NCT05354596

• Pre-surgery ultra-hypofractionated radiation for retroperitoneal soft tissue sarcoma

  This study tests a very short course of pre-surgery high-dose radiation followed by surgery to see if it is safe and manageable for people with retroperitoneal soft tissue sarcoma.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT05224934

• Collecting patient experiences in radiation oncology

  This study is trying to create a tool that collects feedback from cancer patients about the side effects they experience during and after radiation treatment to improve their care.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT05224297

• Registry of patients treated with heavy particle therapy for cancer

  This study is collecting information from cancer patients treated with advanced heavy particle therapy to see how well it works and what side effects it might cause.

  Recruiting CNAO National Center of Oncological Hadrontherapy · Pavia · NCT05203250

• MR‑guided short-course high-dose radiation for prostate cancer (SMART‑P01 & P02)

  This trial tests MR‑guided, very short-course high‑dose radiation for men with localized or limited metastatic prostate cancer to see if it is tolerable and effective.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT05183074

• Using light therapy to prevent and manage vaginal issues from radiotherapy

  This study is testing if light therapy can help women with gynecological cancers prevent and manage vaginal problems caused by radiotherapy.

  Recruiting at 2 sites Jessa Hospital · Genk, Limburg and 1 other locations · NCT05165056

• Using CPAP or BiPAP to reduce tumor movement during radiotherapy

  This study is testing if using CPAP or BiPAP can help control breathing and reduce tumor movement during radiation treatment for patients with lung tumors.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT04986293

• Adaptive radiotherapy for oropharynx cancer

  This study is testing if adjusting radiation treatment using MRI during therapy can help people with advanced throat cancer swallow better after their treatment compared to standard care.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Melbourne and 1 other locations · NCT04901234

• Comparing axillary radiotherapy and lymphadenectomy in breast cancer patients after neoadjuvant therapy

  This study is testing whether using axillary radiotherapy instead of surgery can help breast cancer patients who have had neoadjuvant treatment avoid lymphedema.

  Recruiting at 57 sites Hospital Universitari de Bellvitge · Sydney, New South Wales and 60 other locations · NCT04889924

• Testing different radiation schedules for metastatic prostate cancer

  This study is testing whether a more intense radiation schedule works better and causes fewer side effects for people with newly diagnosed metastatic prostate cancer.

  Recruiting Umeå University · Umeå · NCT04612907

• Comparing 1-week versus 2-week radiotherapy for high-risk breast cancer patients

  This study is testing whether a shorter 1-week radiotherapy treatment is just as effective as a 2-week treatment for patients with high-risk breast cancer after surgery.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT04472845

• Understanding side effects of combined cancer treatments

  This study is trying to see how often severe side effects happen when people with cancer receive both molecular therapies and radiotherapy together compared to when they get them separately.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04115267

• New radiotherapy approach for advanced lung cancer

  This study is testing a new type of radiotherapy for patients with advanced lung cancer who can't have regular treatment to see if it can help them live longer and feel better.

  Recruiting Danish Lung Cancer Group · Aarhus · NCT03742687

• Evaluating the impact of technology in radiotherapy for cancer patients

  This study is trying to see how technology in radiotherapy affects cancer patients by collecting their health information and experiences during treatment.

  Recruiting at 9 sites Centre hospitalier de l'Université de Montréal (CHUM) · Kelowna, British Columbia and 8 other locations · NCT03378856

Related topics

Quick answers

How many Radiotherapy Side Effect clinical trials are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in China (8 trials), Canada (4 trials), Italy (4 trials), Sweden (4 trials), Denmark (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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