Radiotherapy for Head and Neck Cancer with Simultaneous Integrated Boost
Official title: Simultaneous Integrated Boost in the Primary and Adjuvant Therapy of Head and Neck Cancer: Quality Control Registry Prospective Longitudinal Obervation Trial
Run by Wuerzburg University Hospital · NCT06831903 · Data updated 2026-11-12
This study is testing a new type of radiation therapy for people with head and neck cancer to see if it helps them live longer and feel better while causing fewer side effects.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 750 (estimated) |
| Sponsor | Wuerzburg University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Würzburg, Bavaria) |
| Status | Recruiting |
| Started | May 21, 2019 |
| Main results expected | October 1, 2034 |
| Study ends | October 1, 2039 |
| Registry record updated | February 18, 2025 |
| Trial ID | NCT06831903 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with histologically confirmed malignant head and neck tumors who are undergoing definitive or adjuvant radio(chemo)therapy.
✕Probably not a fit
Patients with basal cell carcinoma or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the efficacy and safety of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) in patients with head and neck cancers. It aims to assess local and regional control, overall survival, metastasis-free survival, and therapy-related toxicities while documenting patient-reported quality of life. The study follows a prospective, longitudinal design, collecting real-world outcomes and quality measures in accordance with clinical guidelines. Patients with confirmed malignancies will receive individualized treatment plans designed to minimize toxicity while effectively targeting high-risk tumor areas.
Why it matters
Potential benefit: If successful, this study could improve treatment outcomes and quality of life for patients with head and neck cancers.
How similar studies have gone: Other studies utilizing similar SIB techniques have shown promising results, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 and older with histologically confirmed malignant head and neck tumors, undergoing definitive or adjuvant radio(chemo)therapy at the University Hospital Würzburg Exclusion Criteria: * missing informed consent * mental or physical disorders leading to inability to understand and/or fill the quationary * judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures
Where it's running
-
University Clinic of Wuerzburg
Würzburg, Bavaria, Germany Recruiting
Study contacts
- Principal investigator: Victor Lewitzki, MD, PhD — University Clinic of Wuerzburg, Department of Radiation Oncology
- Study coordinator: Victor Lewitzki, MD, PhD
- Email: lewitzki_v@ukw.de
- Phone: +49-931-201-28869
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Optical surface guidance for head and neck radiotherapy with open-face mask
This trial tests whether using optical surface guidance with an open-face mask during radiotherapy for head and neck cancer improves positioning and reduces movement compared with the standard closed mask approach.
-
Health-Oriented Protocol for Epidermal Radiodermatitis
This study looks at how skin reactions from radiation therapy affect adults with head/neck or pelvic cancers and whether certain factors influence RID outcomes.
-
Comparing dose painting with standard radiotherapy for head and neck cancer
This study is testing a new way of giving radiation treatment for head and neck cancer to see if it causes fewer severe mouth sores than the standard method.
-
Phenotype-based Pain Guidance for Head and Neck Cancer-Related Pain (pilot)
This pilot test sees if tailoring pain treatment to a patient’s pain type can reduce head and neck cancer pain in adults who haven’t started cancer treatment yet.
-
Airway ultrasound in head and neck cancer patients
This observational study tests whether neck ultrasound measurements of the airway match CT measurements in adults with maxillofacial cancer undergoing surgery with anesthesia.
-
Safe use of metformin and naproxen to help prevent cancer in people with Fanconi anemia
This study tests whether metformin and naproxen can lower the chance of cancer developing in adults with Fanconi anemia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.