Partial breast irradiation for early-stage breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of a 2-week schedule of partial breast irradiation compared to a 3-week whole-breast radiotherapy regimen for women with early-stage low-risk breast cancer following breast-conserving surgery. It aims to identify the appropriate patient population and optimal dose fractionation model for partial breast irradiation in the Chinese demographic. The study will enroll women aged 45 to 75 years with specific tumor characteristics and will assess outcomes within a defined timeframe post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ≥45 years old, \<75 years old women
2. Life expectancy \>5 years
3. Start radiotherapy within 12 weeks after breast-conserving surgery (or within 8 weeks from the end of chemotherapy)
4. Invasive ductal carcinoma grade 1-2, or mucinous carcinoma, papillary carcinoma, canalicular carcinoma, medullary carcinoma; primary tumor

   ≤3.0cm; both pN0 (axillary dissection or sentinel lymph node biopsy)
5. Low-risk DCIS: tumor ≤2.5cm, low to medium grade; axillary surgery is not required or pN0
6. Single focus (with MRI diagnosis)
7. Vascular tumor thrombus negative
8. ER and/or PR positivity (defined as strong positivity in \>1% of tumor cell nuclei)
9. Negative pathological margin≥2mm
10. Place metal markers on the tumor bed
11. Sign the informed consent form

Exclusion Criteria:

1. Multiple primary tumors
2. Invasive ductal carcinoma grade 3
3. Invasive micropapillary carcinoma
4. Lobular carcinoma in situ
5. Invasive lobular carcinoma
6. Simple nipple paget's disease
7. Oncoplastic surgery
8. Neoadjuvant chemotherapy or neoadjuvant endocrine therapy
9. Previous or simultaneous contralateral breast cancer
10. History of ipsilateral chest wall radiotherapy
11. Have active collagen vascular disease

Where it's running

• Cancer Hospital ,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Guangyi Sun
• Email: sungy@cicams.ac.cn
• Phone: 086-18811100731

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing 1-week versus 2-week radiotherapy for high-risk breast cancer patients

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• Gyrotonic exercise for elders with breast cancer and Behcet disease

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  Recruiting Cairo University · Giza, Dokki · NCT07929116

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.