Investigating the effects of oral vancomycin on liver disease in adults with primary sclerosing cholangitis.

Who could benefit from this research

What this research studies

This research focuses on adults diagnosed with primary sclerosing cholangitis (PSC), a serious liver condition that can lead to severe complications. Participants will be randomly assigned to receive either oral vancomycin or a placebo to assess its effectiveness in reducing liver inflammation and improving liver function. The study aims to gather data on how this treatment impacts the progression of PSC and its associated symptoms. By participating, patients will contribute to understanding a potential new therapy for a condition that currently has no proven medical treatment.

Why it matters

Where this research is happening

• Mayo Clinic Arizona
  Scottsdale, United States Active

Researchers

• Principal investigator: Carey, Elizabeth — Mayo Clinic Arizona
• Study coordinator: Carey, Elizabeth

Related research

Other NIH-funded projects on the same topics.

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• TAK-781 treatment in healthy adults and people with non-cirrhotic primary sclerosing cholangitis

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  Recruiting Phase 1 Takeda · Salt Lake City, Utah · NCT07229911

• Preventing recurrence of primary sclerosing cholangitis after liver transplantation

  This study is testing if a daily medication called fenofibrate can help prevent primary sclerosing cholangitis from coming back in people who have had a liver transplant.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06905054

• LEOPARD: Predicting liver transplant dropout with AI in European patients

  This project tests new AI-based models to predict which liver transplant candidates are at highest risk of dropout or death while on the waitlist.

  Recruiting at 4 sites Assistance Publique - Hôpitaux de Paris · Ghent, Belgium and 7 other locations · NCT06723275

• Collecting data to improve liver transplantation predictions

  This study is trying to use AI to better predict which liver transplant candidates are at risk of dropping out of the waitlist, so that more people can get fair access to transplants across Europe.

  Recruiting at 53 sites Assistance Publique - Hôpitaux de Paris · Vienna and 52 other locations · NCT06675604

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.