Investigating the effects of oral vancomycin on liver disease in adults with primary sclerosing cholangitis.
A Prospective, Randomized, Multi-centered, Placebo-controlled Clinical Trial of Oral Vancomycin in Adults with Primary Sclerosing Cholangitis
This study is looking for adults with primary sclerosing cholangitis (PSC) to see if taking an oral medication called vancomycin can help reduce liver inflammation and improve liver function, which could lead to better treatment options for this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10474350 on NIH RePORTER |
What this research studies
This research focuses on adults diagnosed with primary sclerosing cholangitis (PSC), a serious liver condition that can lead to severe complications. Participants will be randomly assigned to receive either oral vancomycin or a placebo to assess its effectiveness in reducing liver inflammation and improving liver function. The study aims to gather data on how this treatment impacts the progression of PSC and its associated symptoms. By participating, patients will contribute to understanding a potential new therapy for a condition that currently has no proven medical treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with primary sclerosing cholangitis, particularly those experiencing significant liver-related symptoms.
Not a fit: Patients with other liver diseases or those who have already undergone liver transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that may slow the progression of primary sclerosing cholangitis and improve patients' quality of life.
How similar studies have performed: Previous open-label trials have shown promising results with oral vancomycin in PSC patients, suggesting that this approach may be effective.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Carey, Elizabeth — Mayo Clinic Arizona
- Study coordinator: Carey, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.