Using vancomycin to treat Primary Sclerosing Cholangitis and Biliary Atresia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of vancomycin in treating Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC) while also characterizing the human intestinal microbiome. Researchers will utilize molecular methods to analyze the microbiome's composition and its interactions with the host, focusing on how these factors influence health and disease. The study will assess changes in microbial communities, host gene expression, and blood metabolites in response to vancomycin treatment. The goal is to understand the mechanisms by which vancomycin may affect these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Persons who have primary sclerosing cholangitis, biliary atresia, a chronic intestinal disorder or who are undergoing upper or lower endoscopy.
* Persons who have primary sclerosing cholangitis or biliary atresia who are good candidates for vancomycin therapy.

Exclusion Criteria:

* Patients that have taken antibiotics and/or immunomodulators within the last 3 months will be excluded as this will alter the original bacterial flora.
* Females who are pregnant may not participate.

Where it's running

• Sacramento Pediatric Gastroenterology
  Sacramento, California, United States Recruiting

Study contacts

• Principal investigator: Yinka Davies, M.D. — Sacramento Pediatric Gastroenterology

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.