Condition

Pharmacokinetics clinical trials and research

• 18Clinical trials
• 106NIH research projects
• 2New in 30 days
• 11Countries

Newest Pharmacokinetics clinical trials

All recruiting trials (18)

• Levetiracetam Dosing in Critically Ill on CRRT

  This study tests how levetiracetam behaves in the bodies of adults on continuous renal replacement therapy to help figure out the best dosing.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07918833

• Trigonelline Monohydrate for NAD+ Metabolism in Healthy Adults

  A small study in healthy adults tests whether taking trigonelline monohydrate by mouth for 4 weeks can change NAD+ levels and how the body handles the supplement, compared with NMN and placebo.

  Recruiting Phase 1 dsm-firmenich Switzerland AG · Guelph, Ontario - on · NCT07880925

• Cetuximab bioequivalence test in healthy men

  This study tests whether a cetuximab injection is bioequivalent to Erbitux in healthy men to see if they behave the same in the body.

  Recruiting Phase 1 HC Biopharma Inc. · Haikou, Hainan · NCT07813468

• GenSci142 as a vaginal treatment for bacterial vaginosis

  This study tests whether GenSci142 given as vaginal doses is safe and may help BV patients aged 18–50 compared with clindamycin cream.

  Recruiting at 9 sites Phase 1 Changchun GeneScience Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 8 other locations · NCT07663838

• Food's effect on how DW-1021 (pelubiprofen 45 mg + tramadol 45.9 mg) is absorbed in healthy adults

  This study will test whether eating a high-fat meal changes how DW-1021 (pelubiprofen plus tramadol) is absorbed in healthy adult men.

  Recruiting at 2 sites Phase 1 Haiphong University of Medicine and Pharmacy · Haiphong, Hai Phong and 1 other locations · NCT07060209

• High-potency cannabis effects immediately and after a short break

  This test will try smoked cannabis at about 50 mg and 100 mg THC versus placebo in adults who smoke cannabis nearly every day to see how it affects them right away and after a short period without use.

  Recruiting Phase 1 University of California, Los Angeles · Los Angeles, California · NCT06859723

• Evaluating the safety and tolerability of RCS-21 in healthy volunteers

  This study is testing a new inhaled medication called RCS-21 to see how safe it is and how well it works in healthy volunteers.

  Recruiting Phase 1 RNATICS GmbH · Hanover · NCT06752122

• Safety and blood-level testing of an oral fixed-dose combo of ceftibuten and ledaborbactam etzadroxil

  This will test the safety and how the body processes an oral fixed-dose combination of ceftibuten and ledaborbactam etzadroxil in healthy adults aged 18–55.

  Recruiting Phase 1 Basilea Pharmaceutica · Lenexa, Kansas · NCT06733675

• Comparing two CBD formulations for better absorption in healthy adults

  This study tests whether a new fast-dissolving CBD strip is absorbed better than regular CBD powder in healthy men to help improve how CBD can be used for athletes, especially after concussions.

  Recruiting Phase 1 University of Saskatchewan · Saskatoon, Saskatchewan · NCT06574100

• Assessing how oxycodone and PF614 work together with nafamostat

  This study is testing how well a new combination of oxycodone, PF614, and nafamostat works together to see if it can help prevent overdose in healthy adults aged 18 to 55.

  Recruiting Phase 1 Ensysce Biosciences · Miami, Florida · NCT06500793

• Evaluating antibiotic effectiveness in patients with infections

  This study is testing how well beta-lactam antibiotics work for patients with infections by checking if they get the right amount of the medicine in their system to help them recover.

  Recruiting Imperial College London · London · NCT06427317

• Investigating antibiotic dosing in critically ill children on ECMO

  This study is testing if the current antibiotic doses are strong enough to help critically ill children on ECMO get better.

  Recruiting at 3 sites University Hospital, Ghent · Brussels, Brussels Capital and 2 other locations · NCT06426836

• Investigating the effects of linaprazan glurate on the body and heart

  This study is testing a new medication called linaprazan glurate to see how it affects the body and heart in healthy people.

  Recruiting Phase 1 Cinclus Pharma Holding AB · Uppsala · NCT05469854

• Investigating how caspofungin works in children with severe infections

  This study is testing how well the antifungal drug caspofungin works in children with severe infections to see if the current dosing is right for them.

  Recruiting at 2 sites Children's Hospital of Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT04961593

• Using antibiotics to enhance periodontal treatment effectiveness

  This study is testing different antibiotic treatments to see which ones can help people with gum disease get better after their teeth cleaning.

  Recruiting Phase 4 University of Geneva, Switzerland · Geneva, Canton of Geneva · NCT04669717

• Comparing liposomal bupivacaine and plain bupivacaine for pain management after thoracoscopic surgery

  This study is testing whether a newer form of bupivacaine can help manage pain after thoracoscopic surgery better and safely compared to the regular version.

  Recruiting Phase 4 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT03737292

• Investigating how Posaconazole works in cancer patients receiving chemotherapy or stem cell transplants

  This study is testing how well the antifungal drug Posaconazole works in adults getting chemotherapy or stem cell transplants to see if it can help prevent serious fungal infections.

  Recruiting Phase 4 Melbourne Health · Parkville, Victoria · NCT03717623

• Understanding antibiotic dosing in critically ill children

  This study is trying to find the best antibiotic doses for critically ill children in the hospital to make sure they get effective treatment with fewer side effects.

  Recruiting University Hospital, Ghent · Ghent · NCT02456974

NIH-funded research (newest 40 of 106)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Sub-second acetylcholine release in the brain for Alzheimer’s dementia

  A small, quick stimulations-based study aims to boost a brain chemical called acetylcholine to help people with Alzheimer’s disease by using a targeted brain stimulation approach.

  NIH research Augusta University · Augusta, United States · NIH-11606641

• Understanding how broadly neutralizing antibodies may help HIV cure trials

  A study at UC San Francisco looks at how antibody medicines behave in people on and off HIV therapy to help design better cure strategies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11553282

• Improving HIV-related brain infections by studying how drugs reach the brain

  This grant looks at how well drugs reach the brain and spine to treat HIV-related infections like cryptococcal meningitis and TB meningitis in people with AIDS.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11538505

• Transdermal delivery patch for zanamivir to treat influenza in patients

  A new skin patch delivers zanamivir to people with flu or at risk of flu, aiming for easier, safer treatment than pills.

  NIH research Tsrl, INC. · Ann Arbor, United States · NIH-11534365

• Chesapeake-Ohio Pharmacokinetics Core supports cancer drug testing

  A collaborative core lab helps researchers study how cancer drugs behave in the body to improve clinical trials and patient care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11500210

• Urine color test to check tuberculosis drug levels in children and adults

  This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.

  NIH research University of Virginia · Charlottesville, United States · NIH-11468977

• Making brain-targeted protein degraders work for Alzheimer’s related dementia

  A research project at UC San Diego aims to develop smarter drug molecules that can cross the brain barrier and selectively remove disease-related proteins linked to Alzheimer’s, with potential benefits for people living with dementia.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11454080

• Antibiotic Dosing in Critically Ill Children with Pneumonia

  This project studies how antibiotics reach the lungs of very sick children with bacterial pneumonia and aims to find the best dosing to treat severe infections.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11447105

• How CBD changes THC in cannabis edibles

  This study looks at how different amounts of CBD affect how THC from edibles is absorbed and felt in adults.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11445839

• Designing fluorescent polymers to guide real-time medical imaging

  A project at Texas Tech aims to create design rules that connect how fluorescent polymers are built to how they travel in the body, so imaging can be fast, safe, and informative for patients.

  NIH research Texas Tech University · Lubbock, United States · NIH-11430281

• Metformin and cocaine interactions in the brain

  A study explores whether metformin, a common diabetes medicine, could help treat cocaine use disorder by studying how the drug works in the brain.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11428085

• CAB-LA and Hormones: How Biology Affects HIV Prevention Medicine

  A Johns Hopkins study will look at how natural and added hormones might change how a long-acting HIV prevention drug works in the body.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11424425

• Treatment options for isoniazid-resistant TB: safety, effectiveness, and drug levels with a standard regimen

  This grant studies whether a standard TB treatment plan that includes levofloxacin is safe and effective for people with isoniazid-resistant TB in Peru.

  NIH research Socios En Salud Sucursal Peru · Lima, Peru · NIH-11421427

• Improving HIV-related brain infections with drug levels in the CNS

  This grant studies how drugs reach the brain to better treat HIV-related brain infections like cryptococcal meningitis and TB meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11406184

• PK/PD profiles of mTOR inhibitors in older adults

  This grant studies how two mTOR drugs behave in the bodies of people aged 65 and up to help design safer, more effective aging-related therapies.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11402672

• Optimizing caffeine therapy to protect kidneys and brain in preterm babies

  A randomized study tests whether giving caffeine to very premature babies with kidney and brain hypoxia can reduce kidney injury and improve early brain and kidney outcomes.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11400275

• Gut microbes and malaria: how microbiome interactions influence malaria and drug behavior in people

  Researchers will study how the gut microbiome interacts with malaria infection and how it affects antimalarial drugs in people, using samples from an existing trial and observational cohort.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11399690

• Medicinal chemistry and how drugs behave in the body for cancer research at Ohio State University

  A cancer-focused grant supports scientists at Ohio State University as they make and test new anticancer compounds and study how they behave in the body, including a zebrafish model to check safety and activity.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11397748

• Alcohol after bariatric surgery: how anesthesia-free drinking changes after weight loss surgery

  Aims to understand how bariatric surgery changes how people absorb and feel alcohol so clinicians can guide safer drinking after surgery.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11396970

• Nano-scale sensors to map single cells and mini-tumors metabolism and drug movement

  A Purdue-led project will develop tiny electrochemical sensors to measure many cellular metabolites and how drugs move over time in individual cells and small cell clusters.

  NIH research Purdue University · West Lafayette, United States · NIH-11392301

• Better treatments for brain infections in people with HIV

  Using information about how antifungal and TB drugs reach the brain to help people with HIV who have cryptococcal or TB meningitis get better treatments.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11386303

• Understanding how anti-malarial antibodies work in field settings to protect people

  This grant looks at how monoclonal antibodies against malaria behave in real-world settings to protect people, including children and adults who are exposed to malaria in communities.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11384804

• Phage-based medicines to treat drug-resistant Pseudomonas infections

  Aims to optimize phage-based therapy regimens against tough, drug-resistant Pseudomonas infections to improve how these viruses kill bacteria in real patients.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11375101

• How THC affects people of different ages and sexes

  This project looks at how the body handles and responds to THC taken by mouth or inhaled, in teens, young adults, and older adults.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11360566

• How THC-rich edibles affect how the body processes and responds to cannabis

  This project tests how different edible cannabis formulations change THC levels in the body and the resulting effects in healthy adults.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11359630

• Understanding CFTR Modulators in Pregnancy for Moms and Babies

  We’re studying how CFTR-modifying medicines behave in pregnant people with cystic fibrosis and what that means for moms and their babies.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11357553

• Azathioprine safety and dosing in pregnancy for mothers with autoimmune disease and their babies

  This study looks at how to safely use the drug azathioprine during pregnancy for women with autoimmune diseases and how it affects their infants.

  NIH research Duke University · Durham, United States · NIH-11346965

• Prodrug design to improve how small drugs travel in the body

  A research grant is exploring new ways to attach small drug molecules to carriers so they reach diseased areas more effectively and with fewer side effects.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-11345781

• Investigating the safety and effectiveness of a hepatitis C treatment during pregnancy

  This study is looking at how safe and effective the medications Glecaprevir and Pibrentasvir are for pregnant people with hepatitis C, including those with HIV, and will track their health and their baby's health for three months after birth to make sure everyone stays safe and healthy.

  NIH research Westat, INC. · Rockville, United States · NIH-11344777

• Influence of genetic variants on how COCPs work in women who take them

  This grant will study how genetic differences affect how combined oral contraceptives work in reproductive-age women.

  NIH research Yale University · New Haven, United States · NIH-11333309

• Armored CAR T cells that can be tracked in the body using advanced imaging

  This grant studies enhanced CAR T cells that carry a built-in imageable tag so doctors can see how they move and work inside the body in people with blood cancers and related conditions.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11326428

• How pregnancy and breastfeeding affect antiseizure medicines in moms and babies

  This grant aims to map how antiseizure drugs travel through a pregnant woman’s body and into a baby during pregnancy and breastfeeding to better tailor doses.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11325799

• How oxytocin affects pain and recovery after injury or surgery

  This project measures how oxytocin dose and blood levels relate to pain relief and healing after tissue injury in both animals and people.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11314602

• Generating targeted mouse models to study how drugs are processed in the body

  Researchers are creating precise mouse models to understand how specific liver enzymes called P450s affect drug breakdown and safety.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11298790

• How lung cavities and granulomas affect TB inflammation and drug levels

  This project looks at how damaged lung areas in people with pulmonary tuberculosis influence inflammation and whether antibiotics reach those spots.

  NIH research Emory University · Atlanta, United States · NIH-11285240

• Improving CAR T cell therapy for better tracking and effectiveness

  This study is looking at ways to make CAR T cell therapy better for patients with tough-to-treat B-cell cancers by using special imaging techniques to see how well the treatment is working and to help the engineered T cells find and attack the cancer cells more effectively.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11275273

• Understanding how tafenoquine works in children to prevent malaria relapse

  A pediatric study in the US and other settings will check how tafenoquine behaves in the body to prevent relapses of malaria in kids over 28 days old and at least 12 kg.

  NIH research University of Oxford · Oxford, United Kingdom · NIH-11258574

• Aspirin dose and its effects during pregnancy

  This trial compares two aspirin dosing schedules in pregnant people at high risk for preeclampsia to see which dose better prevents pregnancy complications.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11258547

• Urine color test to monitor TB medicine levels in children and adults

  This project uses a simple urine color measurement to check how well TB medicines, especially rifampin, reach the body in children and adults.

  NIH research University of Virginia · Charlottesville, United States · NIH-11250115

• Comparing how topical medicines are absorbed into the skin using microperfusion

  This project uses a small-sample skin microperfusion method to show whether generic creams, gels, and ointments deliver the same amount of medicine into the skin as brand-name products for people who use topical treatments.

  NIH research Joanneum Research Forschungsgesellschaft Mbh · Graz, Austria · NIH-11247064

Related topics

Quick answers

How many Pharmacokinetics clinical trials are recruiting right now?

18, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (4 trials), China (3 trials), Belgium (2 trials), Canada (2 trials), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 10, Phase 4: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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