Generating targeted mouse models to study how drugs are processed in the body
Official title: Generating P450dTAG knock-in mouse models for drug metabolism and pharmacokinetics
Funded at Baylor College of Medicine · NIH-11298790 · Data updated 2026-11-12
Researchers are creating precise mouse models to understand how specific liver enzymes called P450s affect drug breakdown and safety.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 15, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $764,864 |
| NIH project number | 1R01OD038158-01A1 |
| Project ID | NIH-11298790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people whose doctors are considering drugs heavily metabolized by P450 enzymes and who could participate in future studies validating these models or related translational research.
✕Less likely to help
Patients not taking drugs primarily processed by the targeted P450 enzymes may see limited direct benefit.
What this research studies
This project uses the dTAG system to selectively degrade particular P450 enzymes in mice, allowing researchers to observe changes in drug metabolism without broad developmental side effects. It aims to generate models that reveal how individual enzymes contribute to pharmacokinetics, drug interactions, and potential toxicity. The work could help predict how people metabolize medicines and prevent adverse reactions by clarifying which enzymes matter for what drugs.
Why it matters
Potential benefit: If successful, it could improve drug safety by predicting metabolism and interactions for better dosing and fewer adverse effects.
How similar studies have gone: Previous P450 knockout models have informed metabolism, but this project aims to minimize compensatory effects with the dTAG approach, offering a potentially clearer readout.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Feng — Baylor College of Medicine
- Study coordinator: Li, Feng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.