Medicinal chemistry and how drugs behave in the body for cancer research at Ohio State University
Official title: Core 2: Medicinal Chemistry and Pharmacokinetics Core
Funded at Ohio State University · NIH-11397748 · Data updated 2026-11-12
A cancer-focused grant supports scientists at Ohio State University as they make and test new anticancer compounds and study how they behave in the body, including a zebrafish model to check safety and activity.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2007 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $300,517 |
| NIH project number | 5P01CA125066-17 |
| Project ID | NIH-11397748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with cancers where novel anticancer compounds are being investigated in the broader program, or individuals who may participate in related PK/PK studies via blood or sample donation in future phases.
✕Less likely to help
Patients not in the cancer types targeted by the lead compounds or not involved in any PK/safety studies may not directly benefit.
What this research studies
This grant funds Core 2 to help design, synthesize, modify, and scale up promising anticancer agents and to understand their pharmacokinetic properties. Researchers will use organic and medicinal chemistry, pharmacology, and pharmaceutics to determine how chemical changes affect drug behavior in the body. A zebrafish model will be used to quickly screen for activity and potential toxicity, guiding which compounds move forward. The work complements other projects by providing access to specialized synthesis and PK testing that speeds up the development of effective cancer treatments.
Why it matters
Potential benefit: If successful, the research could streamline the development of new anticancer drugs with better potency and safer profiles, potentially accelerating future therapies for patients.
How similar studies have gone: Previous projects have demonstrated the value of integrated medicinal chemistry and PK work in identifying promising anticancer agents.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Fuchs, James R — Ohio State University
- Study coordinator: Fuchs, James R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.