How CBD changes THC in cannabis edibles
Official title: The Impact of Cannabidiol on the Pharmacokinetics and Pharmacodynamics of Oral Delta-9-Tetrahydrocannabinol
Funded at Johns Hopkins University · NIH-11445839 · Data updated 2026-11-12
This study looks at how different amounts of CBD affect how THC from edibles is absorbed and felt in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $708,190 |
| NIH project number | 1R01DA064583-01A1 |
| Project ID | NIH-11445839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years or older who use or are curious about THC-containing edibles.
✕Less likely to help
Those who do not consume edibles or have no interest in THC/CBD interactions may not directly benefit.
What this research studies
If you use cannabis edibles, this research will examine how CBD in the product changes THC levels in the blood and the user’s experience. The study uses two small, tightly controlled lab studies where participants receive different THC:CBD ratios and doses, without smoking. Participants will be closely monitored for effects on thinking, heart rate, and behavior to understand potential safety implications. The goal is to clarify how CBD alters THC’s impact so consumers can make informed choices in real-world settings.
Why it matters
Potential benefit: If successful, the findings could help people understand safer CBD/THC combinations in edibles and guide label information.
How similar studies have gone: There is prior evidence that CBD can modify THC absorption and effects, but studies with common edibles ratios are limited.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Zamarripa, Carlos Austin — Johns Hopkins University
- Study coordinator: Zamarripa, Carlos Austin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.