Aspirin dose and its effects during pregnancy
Official title: Dose based aspirin pharmacokinetics and pharmacodynamics in pregnancy and association with pregnancy outcomes
Funded at Thomas Jefferson University · NIH-11258547 · Data updated 2026-11-12
This trial compares two aspirin dosing schedules in pregnant people at high risk for preeclampsia to see which dose better prevents pregnancy complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 13, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $663,370 |
| NIH project number | 5R01HD112076-02 |
| Project ID | NIH-11258547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adult pregnant people (single pregnancies) judged to be at high risk for preeclampsia who can start aspirin before 16 weeks of gestation.
✕Less likely to help
People with low-risk pregnancies, multiple gestations, known allergy to aspirin, or those who cannot attend in-person visits are unlikely to benefit or be eligible.
What this research studies
If you join, you would be randomly assigned to take either 81 mg twice daily or 162 mg once daily of aspirin starting before 16 weeks and continuing until 36 weeks. The study plans to enroll about 300 people with a single pregnancy who are at high risk for preeclampsia and will check how well aspirin is working at the start, a few weeks after starting, and again in the late second/early third trimester. Blood tests and a platelet function test will be used to measure aspirin response, and a smaller group of about 50 participants will have intensive 8-hour visits in the first and third trimesters to measure aspirin levels over time. The team will compare aspirin response patterns to pregnancy outcomes to learn which dosing may be most protective.
Why it matters
Potential benefit: If successful, this work could identify a better aspirin dosing approach that lowers the risk of preeclampsia and preterm birth for high-risk pregnancies.
How similar studies have gone: Previous trials showed that low-dose aspirin can reduce preeclampsia risk, but the best dose and how aspirin works across pregnancy are not well established.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Boelig, Rupsa Chaudhury — Thomas Jefferson University
- Study coordinator: Boelig, Rupsa Chaudhury
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.