Condition

Oropharynx Cancer clinical trials and research

• 20Clinical trials
• 9NIH research projects
• 8Countries

Newest Oropharynx Cancer clinical trials

All recruiting trials (20)

• Sacituzumab govitecan plus cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial will test whether combining sacituzumab govitecan with cetuximab works and is safe for people whose head and neck squamous cell cancer has returned or spread after prior immunotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07063212

• Measuring how common high-risk oral HPV is in adults over 40 and testing a screening method for oropharyngeal cancer in the Czech Republic.

  This project will test a simple gargle self-sampling method, with follow-up blood and genital self-tests when needed, to see how common high-risk oral HPV is in people aged 40 and over in the Czech Republic.

  Recruiting at 4 sites The Institute of Molecular and Translational Medicine, Czech Republic · Brno and 4 other locations · NCT07033091

• Methotrexate with erlotinib and celecoxib for recurrent or metastatic head and neck cancer in rural Midwest patients

  This trial tests whether combining methotrexate, erlotinib, and celecoxib can help adults in the rural Midwest whose head and neck cancer has returned or spread.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06997068

• Treatment for head and neck cancer using tailored radiotherapy and ATRA

  This study is testing if a new combination of a cancer drug called ATRA with personalized radiotherapy can help people with certain types of head and neck cancer live longer and feel better.

  Recruiting at 8 sites Phase 3 Centre Leon Berard · Lyon, France and 7 other locations · NCT06706401

• Exploring the links between cancer, undernutrition, and sensory changes

  This study looks at how newly diagnosed cancers in the mouth, throat, colon, and liver affect patients' nutrition and senses like taste and smell, to see how these changes impact their eating habits and quality of life.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT06600295

• Reducing radiation volume in oropharyngeal cancer treatment

  This study is testing a personalized way to reduce radiation for people with oropharyngeal cancer to see if it can lower side effects while still being effective.

  Recruiting at 7 sites Phase 2 University of Zurich · Zurich, Canton of Zurich and 6 other locations · NCT06563362

• Lowering radiation doses for low-risk HPV oropharyngeal cancer patients

  This study is testing if giving a lower dose of radiation to patients with low-risk HPV oropharyngeal cancer after surgery can still be effective while reducing side effects.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT06554158

• Lower dose chemoradiotherapy for elderly patients with HPV-associated oropharynx cancer

  This study is testing a lower dose of radiation and chemotherapy to see if it can help older patients with HPV-related throat cancer while causing fewer side effects than the usual higher doses.

  Recruiting Baptist MD Anderson Cancer Center, Florida · Jacksonville, Florida · NCT06309225

• New blood test to reduce radiation in HPV-related throat cancer treatment

  This study is testing a new blood test to see if it can help identify patients with HPV-related throat cancer who might not need radiation after surgery, aiming to reduce side effects while keeping survival rates high.

  Recruiting at 2 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT06088381

• Targeted radiation therapy for p16+ oropharynx cancer

  This study is testing a targeted radiation therapy for patients with a specific type of throat cancer to see if it helps them live longer and feel better after treatment.

  Recruiting Phase 2 Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT05800574

• Comparing navigation support to standard care for starting radiation therapy in head and neck cancer patients

  This study is testing a new support program to help people with head and neck cancer start their radiation therapy on time compared to the usual care they receive.

  Recruiting at 4 sites Medical University of South Carolina · St Louis, Missouri and 3 other locations · NCT05793151

• New surgical procedure for reconstructing the oral cavity and oropharynx in cancer patients

  This study is testing a new surgical method using a special tissue flap to see if it can safely help cancer patients who need reconstruction in their mouth and throat areas.

  Recruiting at 2 sites Institut Claudius Regaud · Montpellier and 3 other locations · NCT05757817

• Immunotherapy using E7 TCR-T cells for HPV-related cancers

  This study is testing a new immunotherapy using E7 TCR-T cells to see if it can help people with advanced HPV-related cancers like cervical and throat cancer feel better and improve their health.

  Recruiting at 3 sites Phase 2 Rutgers, The State University of New Jersey · Bethesda, Maryland and 2 other locations · NCT05686226

• E7 T-cell therapy for advanced HPV-related cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with advanced cancers linked to HPV feel better and live longer.

  Recruiting at 2 sites Phase 1/2 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT05639972

• Surgery followed by reduced radiation for HPV-positive oropharyngeal cancer

  This study tests how different treatments after surgery can help patients with HPV-positive throat cancer based on their risk level.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05388773

• Care patterns for elderly patients with head and neck cancer receiving radiotherapy

  This study is looking at how well elderly patients with advanced head and neck cancer do with radiation treatment and chemotherapy to see if it helps them live longer and stay healthier.

  Recruiting University Hospital Freiburg · Baltimore, Maryland and 17 other locations · NCT05337631

• Using blood tests to determine treatment timing for HPV-related throat cancer

  This study is testing if blood tests can help decide when to start treatment for people with HPV-related throat cancer after surgery, by checking their tumor DNA levels.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Miami, Florida and 7 other locations · NCT05307939

• Adaptive radiotherapy for oropharynx cancer

  This study is testing if adjusting radiation treatment using MRI during therapy can help people with advanced throat cancer swallow better after their treatment compared to standard care.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Melbourne and 1 other locations · NCT04901234

• Lowering radiation doses in chemotherapy for HPV-positive throat cancer

  This study is testing if giving lower doses of radiation along with regular chemotherapy can help people with HPV-positive throat cancer feel better and have fewer side effects after treatment.

  Recruiting Phase 2 University of Missouri-Columbia · Columbia, Missouri · NCT04444869

• Short-course radiation therapy for oropharynx cancer

  This study is testing a shorter and more targeted radiation treatment for people with HPV-related throat cancer to see if it can reduce side effects while still being effective.

  Recruiting at 2 sites Phase 3 Centre hospitalier de l'Université de Montréal (CHUM) · London, Ontario and 1 other locations · NCT04178174

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• An image-based test to predict risk in HPV-positive throat cancer

  This project aims to develop a simple image- and molecular-based test to show which people with HPV-positive oropharynx (throat) cancer are more likely to have a recurrence so their treatment can be personalized.

  NIH research Washington University · Saint Louis, United States · NIH-11469884

• A new tumor marker (HPVhet) to predict outcomes in HPV-related throat cancer

  This project looks at whether a tumor marker called HPVhet can better predict which people with HPV-positive throat cancer will do well and which might need stronger treatment.

  NIH research Washington University · Saint Louis, United States · NIH-11469883

• Neoadjuvant immunoradiotherapy for HPV-related throat cancer

  A new approach combines targeted radiation before surgery with PD-1 blockade to treat HPV-related oropharyngeal cancer, aiming to improve outcomes and reduce long-term side effects.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11377117

• A test to predict outcomes for HPV-positive oropharynx (throat) cancer using tumor molecular and imaging features

  This project will see if an 'HPVhet' score derived from tumor biology and routine pathology images can help predict outcomes for people with HPV-positive oropharynx cancer.

  NIH research Washington University · Saint Louis, United States · NIH-11301847

• Improving treatment for HPV-related throat cancer before surgery

  This research explores a new way to combine radiation and immunotherapy before surgery for people with HPV-related throat cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11146417

• Detecting HPV-related throat cancer earlier in people with and without HIV

  This study is looking to find better ways to detect HPV-related throat cancer early, especially for people living with HIV, by checking for certain markers in their saliva and blood, which could help improve screening methods in the future.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11058695

• Finding a new way to predict outcomes for patients with oropharynx cancer

  This study is looking to find a new way to help doctors predict how oropharynx cancer might affect patients, especially those with HPV-positive tumors, so they can tailor treatments better and avoid giving unnecessary side effects to those who might not need them.

  NIH research Washington University · Saint Louis, United States · NIH-11040101

• Using immunotherapy and radiation to treat HPV-related throat cancer

  This study is looking at a new way to treat throat cancer caused by HPV by combining special medicines that help your immune system with targeted radiation, aiming to improve how well patients respond to treatment while protecting healthy tissues.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10930922

• Identifying biomarkers in blood and saliva for HPV-related throat cancer

  This study is looking for a way to use a simple test on blood and saliva to find out if people with HPV-related throat cancer have the disease or if it has come back, so they can get the help they need sooner.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10690548

Related topics

Quick answers

How many Oropharynx Cancer clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (13 trials), France (3 trials), Switzerland (2 trials), Czechia (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →