Condition

HPV Positive Oropharyngeal Squamous Cell Carcinoma clinical trials and research

• 18Clinical trials
• 11Countries

Newest HPV Positive Oropharyngeal Squamous Cell Carcinoma clinical trials

All recruiting trials (18)

• Intranasal WSK-IM05 vaccine plus tislelizumab before surgery for HPV‑positive oropharyngeal cancer

  This phase I trial will see if an intranasal WSK‑IM05 vaccine given with the PD‑1 drug tislelizumab before surgery helps people with resectable HPV‑positive oropharyngeal cancer.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07565740

• Lowering nodal and primary tumor radiation dose in HPV-positive oropharyngeal cancer

  This phase II study tests whether reducing radiation doses to regions without visible cancer, while keeping the main tumor dose the same, can treat HPV-positive OPSCC with fewer side effects.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07497607

• Selective dose reduction of neck radiation in HPV-associated oropharyngeal cancer

  This trial tests whether lowering radiation doses to certain neck lymph nodes or gross disease areas is safe and can reduce side effects for adults with HPV-related oropharyngeal cancer.

  Recruiting at 4 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 3 other locations · NCT07418034

• CUE-101 with pembrolizumab for locally advanced HPV‑16 positive oropharyngeal cancer

  This trial tests whether CUE-101 alone or combined with pembrolizumab before definitive therapy helps people with newly diagnosed, locally advanced HPV‑16 positive oropharyngeal cancer who are HLA‑A*02:01 positive.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07172256

• Sacituzumab govitecan plus cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial will test whether combining sacituzumab govitecan with cetuximab works and is safe for people whose head and neck squamous cell cancer has returned or spread after prior immunotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07063212

• BVAC-E6E7 immunotherapy for HPV-positive head and neck cancer

  A one-time immunotherapy shot called BVAC-E6E7 is being tested to see if it helps adults with HPV-positive head and neck cancer that has come back or spread.

  Recruiting at 2 sites Phase 1/2 Cellid Co., Ltd. · Seoul and 1 other locations · NCT06797986

• Evaluating Lenti-HPV-07 Immunotherapy for HPV-Related Cancers

  This study is testing a new immunotherapy called Lenti-HPV-07 to see if it can safely help people with cervical or throat cancers related to HPV.

  Recruiting at 4 sites Phase 1/2 Theravectys S.A. · Orlando, Florida and 3 other locations · NCT06319963

• Lower-dose radiation for non-hypoxic HPV-positive oropharyngeal cancer guided by FMISO PET

  This trial tests whether people with HPV-positive oropharyngeal cancer who show no tumor hypoxia on FMISO PET can be treated safely with a much lower total radiation dose.

  Recruiting Royal North Shore Hospital · Saint Leonards, New South Wales · NCT06307015

• New blood test to reduce radiation in HPV-related throat cancer treatment

  This study is testing a new blood test to see if it can help identify patients with HPV-related throat cancer who might not need radiation after surgery, aiming to reduce side effects while keeping survival rates high.

  Recruiting at 2 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT06088381

• Combining a DNA vaccine with pembrolizumab for HPV-positive head and neck cancer

  This study is testing a new DNA vaccine combined with pembrolizumab to see if it helps people with advanced HPV-positive head and neck cancer.

  Recruiting at 12 sites Phase 1/2 Nykode Therapeutics ASA · Montpellier and 11 other locations · NCT06016920

• Immunotherapy using E7 TCR-T cells for HPV-related cancers

  This study is testing a new immunotherapy using E7 TCR-T cells to see if it can help people with advanced HPV-related cancers like cervical and throat cancer feel better and improve their health.

  Recruiting at 3 sites Phase 2 Rutgers, The State University of New Jersey · Bethesda, Maryland and 2 other locations · NCT05686226

• E7 T-cell therapy for advanced HPV-related cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with advanced cancers linked to HPV feel better and live longer.

  Recruiting at 2 sites Phase 1/2 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT05639972

• Reduced radiation treatment for HPV-positive throat cancer

  This study is testing if a lower dose of radiation can effectively treat HPV-positive throat cancer while causing fewer side effects for patients.

  Recruiting University of California, Irvine · Orange, California · NCT05600842

• Robotic surgery for HPV-related throat cancer

  This study is testing if robotic surgery can be a safe and effective treatment for patients with HPV-related throat cancer who have low levels of cancer markers after surgery, to see if it works as well as traditional treatments without the harsh side effects.

  Recruiting at 2 sites Phase 2 Icahn School of Medicine at Mount Sinai · Paramus, New Jersey and 1 other locations · NCT05419089

• Using blood tests to determine treatment timing for HPV-related throat cancer

  This study is testing if blood tests can help decide when to start treatment for people with HPV-related throat cancer after surgery, by checking their tumor DNA levels.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Miami, Florida and 7 other locations · NCT05307939

• Tailored treatment for HPV-positive oropharyngeal cancer using blood tests

  This study is testing a new way to tailor treatment for people with HPV-related throat cancer by using blood tests to see if adjusting their radiation and chemotherapy can improve their outcomes.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04900623

• Lowering radiation doses in chemotherapy for HPV-positive throat cancer

  This study is testing if giving lower doses of radiation along with regular chemotherapy can help people with HPV-positive throat cancer feel better and have fewer side effects after treatment.

  Recruiting Phase 2 University of Missouri-Columbia · Columbia, Missouri · NCT04444869

• Reducing treatment intensity for HPV-positive throat cancer

  This study is testing whether giving less intense treatment for HPV-positive throat cancer can still help patients do well and feel better during and after their care.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT03215719

Related topics

Quick answers

How many HPV Positive Oropharyngeal Squamous Cell Carcinoma clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (14 trials), France (1 trial), Germany (1 trial), Hungary (1 trial), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 1/2: 4, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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