Condition

Oral Squamous Cell Carcinoma clinical trials and research

• 17Clinical trials
• 21NIH research projects
• 1New in 30 days
• 6Countries

Newest Oral Squamous Cell Carcinoma clinical trials

All recruiting trials (17)

• Salivary IL-8 and Serum IL-6 as Biomarkers to Distinguish Oral Premalignant Disorders in Smokers and Never-Smokers

  This study tests whether salivary IL-8 and blood IL-6 can help tell apart adults with oral premalignant conditions from those with healthy mouths, and whether smoking influences these markers.

  Recruiting British University In Egypt · Cairo · NCT07915570

• Docetaxel and SX-682 in head and neck cancers and prostate cancer

  This trial tests a new drug SX-682 together with docetaxel in adults whose head and neck cancers or prostate cancer have returned or spread.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07667400

• Patient-specific 3D-printed titanium implants for facial reconstruction

  This study tests whether custom-made 3D-printed titanium facial implants can improve reconstruction and appearance for adults with facial bone defects or asymmetry.

  Recruiting Latakia University · Latakia · NCT07654647

• Comparing dual-energy CT and MRI for staging oral and oropharyngeal squamous cell carcinoma

  This will test whether 40 keV dual-energy CT can replace a contrast-enhanced neck and facial MRI for staging adults with oral or oropharyngeal squamous cell carcinoma.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07343271

• Sacituzumab govitecan plus cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial will test whether combining sacituzumab govitecan with cetuximab works and is safe for people whose head and neck squamous cell cancer has returned or spread after prior immunotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07063212

• Pre-surgery metronidazole and chlorhexidine to lower bacteria in oral cavity tumors

  This study will try a short course of the antibiotic metronidazole plus chlorhexidine mouthwash before surgery to see if it lowers bacteria inside tumors in adults with oral squamous cell carcinoma.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06627270

• Using ultrasound to improve diagnosis of oral cancer

  This study is testing a new ultrasound technique to see if it can help doctors better diagnose oral cancer in patients.

  Recruiting University of Pisa · Pisa · NCT06336941

• Using Optical Coherence Tomography to Diagnose Oral Cancer

  This study is testing if a special imaging technique called Optical Coherence Tomography can help doctors find oral cancer earlier and more accurately in patients with potentially harmful mouth conditions.

  Recruiting University of Palermo · Palermo · NCT06321003

• Neoadjuvant immunochemotherapy for advanced oral cancer

  This study is testing a new combination of immunotherapy and chemotherapy to see if it can shrink tumors in people with advanced oral cancer before they have surgery, and if it helps them live longer compared to standard treatments.

  Recruiting Phase 3 Huashan Hospital · Shanghai · NCT06258811

• Testing a new saliva test for oral and throat cancer

  This study is testing a new saliva test to see if it can help find oral and throat cancers in people who might have them.

  Recruiting at 2 sites Viome · St Louis, Missouri and 1 other locations · NCT06174428

• Testing new treatments for oral squamous cell carcinoma

  This study is testing two new treatments for oral squamous cell carcinoma to see if they are safe and effective for patients after surgery.

  Recruiting at 4 sites Phase 2/3 Privo Technologies · Duarte, California and 3 other locations · NCT05893888

• Neoadjuvant treatment for advanced oral cancer using Tislelizumab and chemotherapy

  This study is testing if a new combination of Tislelizumab and chemotherapy can help people with advanced oral cancer before their surgery.

  Recruiting Phase 2 Zhejiang University · Hangzhou · NCT05862168

• Saliva DNA methylation test for diagnosing oral cavity squamous cell carcinoma

  This tests whether a saliva DNA methylation test can detect oral squamous cell carcinoma in adults scheduled for maxillofacial surgery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT05791149

• Detecting oral and throat cancers using a saliva test

  This study is testing a saliva test to see if it can help detect oral and throat cancers early in people, including those who are healthy and those with existing conditions.

  Recruiting Viome · New York, New York · NCT05451303

• Comparing two treatment approaches for advanced oral squamous cell carcinoma

  This study is testing whether a new combination treatment for advanced oral cancer can work better than the standard treatment to help patients before surgery.

  Recruiting Phase 2/3 Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT05125055

• Combining sintilimab with reduced chemotherapy for oral cavity cancer treatment

  This study is testing if combining a new immune therapy called sintilimab with fewer chemotherapy sessions can help people with certain types of mouth cancer before they have surgery.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT05098119

• Personalized anti-PD-1 and anti-VEGFR therapy for oral cancer patients

  This study is testing a personalized treatment combining two medications for patients with advanced oral cancer to see if it helps them stay cancer-free for longer after surgery.

  Recruiting Phase 2 Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT05069857

NIH-funded research (21)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Oral cancer recurrence predictor using tumor microbes and gene activity

  This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11591548

• Reducing bacteria inside oral cancer tumors to boost immune response

  In people with head and neck cancer, this study tests whether lowering bacteria in tumors can help the immune system fight the cancer better.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11439220

• REASON Score: an epigenetic and clinicopathologic approach to predict survival risk in early oral cancer

  A new biomarker-based score using DNA methylation and clinicopathology to predict survival risk for people with early-stage oral squamous cell carcinoma.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11372175

• New vulnerability in oral cancer linked to p53 loss

  A cancer research grant is exploring a surprising weakness in head and neck cancer to help people with HPV-negative oral squamous cell carcinoma.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11370165

• Mouth bacteria that may speed up oral cancer

  This work looks at whether specific mouth bacteria help oral squamous cell carcinoma grow and spread in people who have or are at risk for oral cancer.

  NIH research Oklahoma State University Stillwater · Stillwater, United States · NIH-11335589

• Targeting a stress-specific function of a DNA replication protein to boost oral cancer therapy

  A short, targeted NIH grant explores a new way to make existing treatments work better for oral cancer by attacking a special function of a DNA replication protein that cancer cells rely on.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11321521

• AI-powered miRNA test to tell oral cancer from benign leukoplakia without surgery

  A noninvasive brush-based test using artificial intelligence analyzes tiny RNA patterns to distinguish oral cancer from benign oral lesions, helping people avoid delays.

  NIH research Arphion, LTD · Chicago, United States · NIH-11314925

• Immune clues for preventing oral cancer from early lesions

  A doctor-scientist team will look at how the immune system behaves in early mouth lesions to predict which ones become cancer and how to intervene earlier.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11301814

• How acetylcholine may help immune cells fight oral cavity cancer

  This project looks at whether the natural chemical acetylcholine helps memory T cells keep fighting oral cavity (oral squamous cell) cancer so immunotherapy works better for patients.

  NIH research New York University School of Medicine · New York, United States · NIH-11140523

• Investigating how a specific protein affects oral cancer growth

  This study is looking at how a protein called LOX-PP affects the growth of oral cancer and the way the immune system responds, with the goal of finding new ways to improve treatment for people with oral squamous cell carcinoma.

  NIH research Ada Forsyth Institute, INC. · Cambridge, United States · NIH-11139198

• A new way to understand oral cancer risk

  This project aims to create a better tool to help doctors understand the risk of early-stage oral cancer returning or getting worse, so patients can receive the most effective treatment.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11103260

• Understanding how TRIP13 contributes to radiation resistance in oral cancer

  This study is looking at a protein called TRIP13 that helps some oral cancer cells survive radiation treatment, and by understanding how it works, the researchers hope to find ways to make these tumors more responsive to radiation, which could lead to better treatment options for patients.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11080749

• Investigating the role of Follistatin in oral cancer progression

  This study is looking at how a protein called Follistatin affects mouth cancer, aiming to find new ways to diagnose and treat this type of cancer by understanding how it helps the cancer grow and spread.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11067208

• Understanding how the immune system affects the progression of oral pre-cancer to cancer

  This study is looking at how the immune system affects whether a condition called oral epithelial dysplasia turns into oral cancer, so that patients with this condition can get better monitoring and personalized treatments based on their immune responses.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11060001

• Investigating how aging affects oral cancer development

  This study is looking at how changes in the mouth as we age might affect the growth of head and neck cancer, with the hope of finding better treatment options for older patients.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11042710

• Targeting a specific protein to improve treatment for oral cancer

  This study is exploring a new way to treat oral squamous cell carcinoma by targeting a specific protein that helps cancer cells repair their DNA, with the goal of making treatments like chemotherapy and radiation work better while being gentler on your body.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11034662

• Investigating how oral pathogens contribute to the progression of oral cancer

  This study is looking at how certain bacteria in your mouth might affect the growth of oral cancer, and it’s for people who have or are at risk for oral squamous cell carcinoma, as they may help by sharing samples or information about their oral health.

  NIH research Oklahoma State University Stillwater · Stillwater, United States · NIH-11014470

• Investigating how a neurotransmitter affects immune responses in oral cancer

  This study is looking at how a chemical in the body called acetylcholine helps certain immune cells fight oral cancer, with the goal of finding better ways to improve treatments for patients with this type of cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-10987548

• Investigating how TGF Beta1 affects tissue changes in metastatic oral cancer

  This study is looking at how a protein called TGFβ affects the spread of oral cancer and how it interacts with the surrounding tissue and immune cells, with the hope of finding new ways to treat patients better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10983354

• Investigating how serine metabolism affects oral cancer development

  This study is looking at how changes in a substance called serine might affect the behavior of oral squamous cell carcinoma, a tough-to-treat type of cancer, to help find better ways to manage and treat it for patients like you.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10929416

• How mTORC1 affects oral cancer growth and signaling

  This study is looking at how a protein called mTORC1 affects the growth of mouth cancer cells by seeing where it is located inside the cells, which could help find new ways to treat this type of cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10917109

Related topics

Quick answers

How many Oral Squamous Cell Carcinoma clinical trials are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), China (5 trials), France (2 trials), Italy (2 trials), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 2/3: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →