Condition

Oropharyngeal Squamous Cell Carcinoma clinical trials and research

• 21Clinical trials
• 8Countries

Newest Oropharyngeal Squamous Cell Carcinoma clinical trials

All recruiting trials (21)

• Docetaxel and SX-682 in head and neck cancers and prostate cancer

  This trial tests a new drug SX-682 together with docetaxel in adults whose head and neck cancers or prostate cancer have returned or spread.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07667400

• Lowering nodal and primary tumor radiation dose in HPV-positive oropharyngeal cancer

  This phase II study tests whether reducing radiation doses to regions without visible cancer, while keeping the main tumor dose the same, can treat HPV-positive OPSCC with fewer side effects.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07497607

• Selective dose reduction of neck radiation in HPV-associated oropharyngeal cancer

  This trial tests whether lowering radiation doses to certain neck lymph nodes or gross disease areas is safe and can reduce side effects for adults with HPV-related oropharyngeal cancer.

  Recruiting at 4 sites Phase 2 University of Maryland, Baltimore · Baltimore, Maryland and 3 other locations · NCT07418034

• Comparing dual-energy CT and MRI for staging oral and oropharyngeal squamous cell carcinoma

  This will test whether 40 keV dual-energy CT can replace a contrast-enhanced neck and facial MRI for staging adults with oral or oropharyngeal squamous cell carcinoma.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07343271

• Personalized compartment-sparing postoperative radiation for head and neck cancer

  This trial tests whether targeted, compartment-sparing postoperative radiation can reduce side effects while keeping cancer control for people with surgically treated head and neck squamous cell carcinoma.

  Recruiting at 3 sites Phase 2 Insel Gruppe AG, University Hospital Bern · Basel and 2 other locations · NCT07058805

• Shorter radiation after trans-oral robotic surgery for HPV-related oropharyngeal cancer

  This trial tests whether giving a shorter course of radiation after trans-oral robotic surgery helps people with HPV-related oropharyngeal cancer have better quality of life.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT07044635

• Cemiplimab with or without CDX-1140 given before surgery for stage III-IV head and neck cancer

  This trial tests whether adding the immune stimulant CDX-1140 to cemiplimab before surgery helps shrink tumors in people with resectable stage III-IV head and neck squamous cell carcinoma.

  Recruiting at 12 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 11 other locations · NCT06980038

• Comparing two imaging techniques for assessing blood vessel effects in head and neck cancer patients receiving radiation therapy

  This study is testing if a new type of imaging can better spot blood vessel problems in head and neck cancer patients getting radiation therapy compared to the usual imaging method.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06914999

• Remote hearing tests for patients with head and neck cancer receiving chemotherapy or radiation

  This study is testing if remote hearing tests can help patients with advanced head and neck cancer keep track of their hearing loss during chemotherapy or radiation, making it easier for those who live far away to participate.

  Recruiting Emory University · Atlanta, Georgia · NCT06662058

• Adding BMX-001, a drug that protects normal tissue from radiation damage, to standard chemoradiation for head and neck cancer

  This trial tests whether giving BMX-001 along with usual mouth-care reduces severe mouth sores in people getting cisplatin-based chemoradiation for HPV-related and other head and neck cancers.

  Recruiting at 146 sites Phase 2 NRG Oncology · Gilbert, Arizona and 152 other locations · NCT06532279

• Identifying biomarkers for HPV-related oropharyngeal cancer

  This study is trying to find specific markers in blood and saliva that can help identify HPV-related throat cancer in patients who are already diagnosed with advanced stages of the disease.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06356272

• Lower dose radiation therapy guided by blood tests for HPV-related throat cancer

  This study is testing if using blood tests to guide lower doses of radiation therapy can help people with HPV-related throat cancer do better than the usual treatment.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06323460

• Testing a new saliva test for oral and throat cancer

  This study is testing a new saliva test to see if it can help find oral and throat cancers in people who might have them.

  Recruiting at 2 sites Viome · St Louis, Missouri and 1 other locations · NCT06174428

• Using blood tests to monitor head and neck cancer

  This study is testing if blood tests can help monitor treatment and detect early relapse in people with HPV-related throat cancer.

  Recruiting at 2 sites University of Edinburgh · Dundee, DD2 1SG and 4 other locations · NCT05539638

• Registry of Genetic Changes in Oropharyngeal Cancer in Taiwan

  This study is trying to find genetic changes in oropharyngeal cancer in Taiwanese patients to help create better treatments for both HPV positive and negative cases.

  Recruiting at 7 sites National Health Research Institutes, Taiwan · Kaohsiung City and 6 other locations · NCT05522881

• Personalized neck irradiation for head and neck cancer based on lymph node biopsy results

  This study is testing if using biopsy results to personalize neck radiation can help people with laryngeal and pharyngeal cancer avoid unnecessary treatment and improve their quality of life.

  Recruiting at 7 sites Phase 3 Radboud University Medical Center · Amsterdam and 8 other locations · NCT05333523

• Reducing chemotherapy and radiation for certain throat cancers

  This study is testing a lighter treatment plan for certain throat cancers to see if it can work just as well as stronger chemotherapy and radiation while causing fewer side effects.

  Recruiting at 3 sites Phase 2 University of Florida · Gainesville, Florida and 2 other locations · NCT05268614

• Combining sintilimab with reduced chemotherapy for oral cavity cancer treatment

  This study is testing if combining a new immune therapy called sintilimab with fewer chemotherapy sessions can help people with certain types of mouth cancer before they have surgery.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT05098119

• CUE-101 treatment before surgery for HPV16-positive throat cancer

  This study is testing a new treatment called CUE-101 to see if it is safe and helps people with HPV16-positive throat cancer before they have their regular treatment, like surgery or radiation.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT04852328

• Observing HPV DNA and genetic markers in oropharyngeal cancer

  This study is testing if checking for certain gene changes and HPV DNA in the blood can help predict if oropharyngeal cancer will come back in newly diagnosed patients.

  Recruiting at 2 sites UNC Lineberger Comprehensive Cancer Center · Rochester, Minnesota and 2 other locations · NCT04564989

• Comparing radiotherapy and trans-oral surgery for HPV-negative oropharyngeal cancer

  This study is testing whether radiotherapy or trans-oral surgery works better as the first treatment for early-stage HPV-negative throat cancer.

  Recruiting Phase 2 London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT04220749

Related topics

Quick answers

How many Oropharyngeal Squamous Cell Carcinoma clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (14 trials), Canada (1 trial), Taiwan (1 trial), France (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Early Phase 1: 1, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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