How mTORC1 affects oral cancer growth and signaling
Official title: Spatial regulation of mechanistic target of rapamycin complex 1 (mTORC1) and its role in oral squamous cell carcinoma
Funded at University of California, San Diego · NIH-10917109 · Data updated 2026-11-12
This study is looking at how a protein called mTORC1 affects the growth of mouth cancer cells by seeing where it is located inside the cells, which could help find new ways to treat this type of cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $43,669 |
| NIH project number | 5F31DE032886-02 |
| Project ID | NIH-10917109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with oral squamous cell carcinoma who are seeking innovative treatment options.
✕Less likely to help
Patients with other types of cancers or those without a diagnosis of oral squamous cell carcinoma may not benefit from this research.
What this research studies
This research investigates the role of a protein complex called mTORC1 in oral squamous cell carcinoma, focusing on how its location within cells influences cancer cell growth and behavior. The study uses advanced techniques, including genetically encoded fluorescent biosensors, to observe mTORC1 activity in real-time within living cells. By understanding how mTORC1 operates in different parts of the cell, particularly in the nucleus, the researchers aim to uncover new insights into cancer biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating oral squamous cell carcinoma by targeting the mTORC1 signaling pathway.
How similar studies have gone: Previous research has shown promising results in targeting mTORC1 in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Sahan, Ayse Zisan — University of California, San Diego
- Study coordinator: Sahan, Ayse Zisan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.