Investigating how oral pathogens contribute to the progression of oral cancer
Official title: Oral Pathogen-triggered Progression of Oral Squamous Cell Carcinoma
Funded at Oklahoma State University Stillwater · NIH-11014470 · Data updated 2026-11-12
This study is looking at how certain bacteria in your mouth might affect the growth of oral cancer, and it’s for people who have or are at risk for oral squamous cell carcinoma, as they may help by sharing samples or information about their oral health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $228,362 |
| NIH project number | 5P20GM152333-02 |
| Project ID | NIH-11014470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with oral squamous cell carcinoma or those at high risk due to factors like tobacco and alcohol use.
✕Less likely to help
Patients without a history of oral cancer or significant risk factors related to oral pathogens may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific oral pathogens in the development and progression of oral squamous cell carcinoma (OSCC), the most common type of oral cancer. By analyzing the oral microbiome, the study aims to identify how certain bacteria, particularly Prevotella intermedia, influence cancer cell behavior. The researchers will explore the mechanisms by which these pathogens may enhance cancer cell proliferation and migration, potentially leading to new insights into cancer treatment and prevention. Patients may be involved in providing samples or participating in assessments related to their oral health and cancer status.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating oral cancer by targeting specific oral pathogens.
How similar studies have gone: Previous studies have shown that certain oral pathogens are linked to cancer progression, suggesting that this research builds on established findings in the field.
Where this research is happening
-
Oklahoma State University Stillwater
Stillwater, United States Active
Researchers
- Principal investigator: Huang, I-Hsiu — Oklahoma State University Stillwater
- Study coordinator: Huang, I-Hsiu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.