Investigating how a specific protein affects oral cancer growth
Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments
['FUNDING_OTHER'] · ADA FORSYTH INSTITUTE, INC. · NIH-11139198
This study is looking at how a protein called LOX-PP affects the growth of oral cancer and the way the immune system responds, with the goal of finding new ways to improve treatment for people with oral squamous cell carcinoma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ADA FORSYTH INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11139198 on ClinicalTrials.gov |
What this research studies
This research focuses on oral squamous cell carcinoma (OSCC), a common type of oral cancer, and examines the role of lysyl oxidase propeptide (LOX-PP) in tumor growth and microenvironments. The study aims to understand how variations in the LOX-PP protein can influence cancer progression and the immune response in the oral cavity. By analyzing the interactions between LOX-PP and immune cells, the researchers hope to identify mechanisms that could lead to new therapeutic strategies for OSCC. Patients may benefit from insights that could improve treatment outcomes and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral squamous cell carcinoma, particularly those with specific genetic variations in the LOX-PP protein.
Not a fit: Patients with other types of cancers or those without oral squamous cell carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit tumor growth and improve the quality of life for patients with oral cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of lysyl oxidase in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- ADA FORSYTH INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRACKMAN, PHILIP C — ADA FORSYTH INSTITUTE, INC.
- Study coordinator: TRACKMAN, PHILIP C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.