Investigating how a specific protein affects oral cancer growth
Official title: Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments
Funded at Ada Forsyth Institute, INC. · NIH-11139198 · Data updated 2026-11-12
This study is looking at how a protein called LOX-PP affects the growth of oral cancer and the way the immune system responds, with the goal of finding new ways to improve treatment for people with oral squamous cell carcinoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 15, 2024 |
| Project end | September 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $612,048 |
| NIH project number | 1R56DE033090-01A1 |
| Project ID | NIH-11139198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with oral squamous cell carcinoma, particularly those with specific genetic variations in the LOX-PP protein.
✕Less likely to help
Patients with other types of cancers or those without oral squamous cell carcinoma may not benefit from this research.
What this research studies
This research focuses on oral squamous cell carcinoma (OSCC), a common type of oral cancer, and examines the role of lysyl oxidase propeptide (LOX-PP) in tumor growth and microenvironments. The study aims to understand how variations in the LOX-PP protein can influence cancer progression and the immune response in the oral cavity. By analyzing the interactions between LOX-PP and immune cells, the researchers hope to identify mechanisms that could lead to new therapeutic strategies for OSCC. Patients may benefit from insights that could improve treatment outcomes and quality of life.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit tumor growth and improve the quality of life for patients with oral cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of lysyl oxidase in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Trackman, Philip C — Ada Forsyth Institute, INC.
- Study coordinator: Trackman, Philip C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.